Clinical characteristics and chest computed tomography findings of smear-positive and smear-negative pulmonary tuberculosis in hospitalized adult patients
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DOI: 10.1097/md.0000000000016921
Abstract: Abstract Pulmonary tuberculosis (PTB) continues to be one of the significant public health threats with significant morbidity and mortality. The present study was aimed to assess the clinical characteristics and chest computed tomography (CT) findings… read more here.
Keywords: smear negative; adult patients; tuberculosis; hospitalized adult ... See more keywords
Role of bronchoalveolar lavage fluid and serum interleukin-27 in the diagnosis of smear-negative pulmonary tuberculosis
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DOI: 10.1097/md.0000000000025821
Abstract: Abstract Background: To evaluate the value of interleukin (IL)-27 measured in serum and bronchoalveolar lavage fluid (BALF) for the diagnosis of smear-negative pulmonary tuberculosis (TB). Methods: This was a prospective study of patients planned to… read more here.
Keywords: diagnosis; serum; bronchoalveolar lavage; lavage fluid ... See more keywords
Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis
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DOI: 10.1128/jcm.00531-18
Abstract: Most cases of multidrug-resistant (MDR) tuberculosis (TB) are never diagnosed (328,300 of the ∼490,000 cases in 2016 were missed). The Xpert MTB/RIF assay detects resistance only to rifampin, despite ∼20% of rifampin-resistant cases being susceptible… read more here.
Keywords: fluorotype; smear negative; tuberculosis; multidrug resistant ... See more keywords
Chest X-ray interpretation does not complement Xpert MTB/RIF in diagnosis of smear-negative pulmonary tuberculosis among TB-HIV co-infected adults in a resource-limited setting
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DOI: 10.1186/s12879-020-05752-7
Abstract: Background Chest X-ray (CXR) interpretation remains a central component of the current World Health Organization recommendations as an adjuvant test in diagnosis of smear-negative tuberculosis (TB). With its low specificity, high maintenance and operational costs,… read more here.
Keywords: cxr; interpretation; diagnosis; smear negative ... See more keywords
Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso
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DOI: 10.1371/journal.pone.0242507
Abstract: Asymptomatic malaria infections may affect red blood cell (RBC) homeostasis. Reports indicate a role for chronic hemolysis and splenomegaly, however, the underlying processes are incompletely understood. New hematology analysers provide parameters for a more comprehensive… read more here.
Keywords: red blood; smear negative; clinical malaria; blood ... See more keywords
Persistent expression of activation markers on Mycobacterium tuberculosis-specific CD4 T cells in smear negative TB patients
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DOI: 10.1371/journal.pone.0271234
Abstract: Background T cell activation (HLA-DR, CD-38), proliferation (KI-67), and functional (IFN-γ, TNF-α) markers have recently been shown to be useful in predicting and monitoring anti-TB responses in smear positive TB, but previous research did not… read more here.
Keywords: cd4 cells; activation markers; smear negative; specific cd4 ... See more keywords
Effectiveness of Endobronchial Ultrasound-Guided Transbronchial Biopsy Combined With Tissue Culture for the Diagnosis of Sputum Smear-Negative Pulmonary Tuberculosis
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DOI: 10.3389/fmicb.2022.847479
Abstract: Background Microorganisms of tuberculosis (TB) are frequently difficult to identify from the airway specimen; therefore, lung biopsy for further histologic and microbiologic study is required. Endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB) is used for the diagnosis… read more here.
Keywords: culture; sputum smear; tissue culture; ebus ... See more keywords
Next-Generation Metagenome Sequencing Shows Superior Diagnostic Performance in Acid-Fast Staining Sputum Smear-Negative Pulmonary Tuberculosis and Non-tuberculous Mycobacterial Pulmonary Disease
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DOI: 10.3389/fmicb.2022.898195
Abstract: In this study, we explored the clinical value of next-generation metagenome sequencing (mNGS) using bronchoalveolar lavage fluid (BALF) samples from patients with acid-fast staining (AFS) sputum smear-negative pulmonary tuberculosis (PTB) and non-tuberculous mycobacterial pulmonary disease… read more here.
Keywords: spot; metagenome sequencing; sputum smear; generation metagenome ... See more keywords
The Diagnostic Value of the Thermostatic Amplification of Ribonucleic Acid in Bronchoalveolar Lavage Fluid in Smear-Negative Pulmonary Tuberculosis
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DOI: 10.3389/fpubh.2022.830477
Abstract: Objective This study aimed to determine the value of the simultaneous amplification and testing for Mycobacterium tuberculosis in bronchoalveolar lavage fluid (BALF) in the diagnosis of smear-negative pulmonary tuberculosis (PTB). Methods A total of 316… read more here.
Keywords: bronchoalveolar lavage; tuberculosis; amplification; smear negative ... See more keywords
Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis
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DOI: 10.4103/ijpm.ijpm_72_21
Abstract: Background and Aims: The host immune system plays an important role in the pathogenesis and defense mechanism of Mycobacterium tuberculosis (Mtb). This study aimed to explore the different changes in the immune system between smear-negative… read more here.
Keywords: negative pulmonary; ptb; pulmonary tuberculosis; smear negative ... See more keywords