Mycobacteriophage SWU1-Functionalized magnetic particles for facile bioluminescent detection of Mycobacterium smegmatis.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.12.009
Abstract: Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, ranks one of the most dangerous pathogens for its large deaths toll. Due to its characteristic extremely slow growth, the conventional culture-based protocol cannot meet the requirement… read more here.
Keywords: mycobacterium; smegmatis; mycobacteriophage swu1; tuberculosis ... See more keywords
MksB, an alternate condensin from Mycobacterium smegmatis is involved in DNA binding and condensation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.03.002
Abstract: The structural maintenance of chromosomes (SMC) proteins play a vital role in genome stability and chromosome organization in all domains of life. Previous reports show that smc deletion causes decondensation of chromosome and an increased… read more here.
Keywords: mycobacterium; dna; condensation; dna binding ... See more keywords
Mutation in Eth A protein of Mycobacterium tuberculosis conferred drug tolerance against enthinoamide in Mycobacterium smegmatis mc2155.
Sign Up to like & getrecommendations! Published in 2022 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2022.107677
Abstract: EthA is an NADPH-specific flavin adenine dinucleotide (FAD) containing monooxygenase that activates the -second-line drug ethionamide (ETH). ETH gets converted to an active form after interaction with the EthA (monooxygenase) protein. Upon activation, ETH interacts… read more here.
Keywords: drug; smegmatis; etha; protein ... See more keywords
The bifunctional protein GlmU is a key factor in biofilm formation induced by alkylating stress in Mycobacterium smegmatis.
Sign Up to like & getrecommendations! Published in 2019 at "Research in microbiology"
DOI: 10.1016/j.resmic.2019.03.002
Abstract: Living organisms have developed specific defence mechanisms to counteract hostile environmental conditions. Alkylation stress response mechanisms also occur in Mycobacterium tuberculosis (MTB) the pathogen responsible for tuberculosis. The effect of alkylating agents on the cellular… read more here.
Keywords: glmu; biofilm formation; stress; smegmatis ... See more keywords
Assessment of Metabolic Changes in Mycobacterium smegmatis Wild-Type and alr Mutant Strains: Evidence of a New Pathway of d-Alanine Biosynthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00871
Abstract: In mycobacteria, d-alanine is an essential precursor for peptidoglycan biosynthesis. The only confirmed enzymatic pathway to form d-alanine is through the racemization of l-alanine by alanine racemase (Alr, EC 5.1.1.1). Nevertheless, the essentiality of Alr… read more here.
Keywords: alanine; biosynthesis; alr; smegmatis ... See more keywords
Mycobacterial DNA-binding protein 1 is critical for long term survival of Mycobacterium smegmatis and simultaneously coordinates cellular functions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06480-w
Abstract: Bacteria can proliferate perpetually without ageing, but they also face conditions where they must persist. Mycobacteria can survive for a long period. This state appears during mycobacterial diseases such as tuberculosis and leprosy, which are… read more here.
Keywords: mycobacterium; term; long term; smegmatis ... See more keywords
TLR-2 mediated cytosolic-Ca2+ surge activates ER-stress-superoxide-NO signalosome augmenting TNF-α production leading to apoptosis of Mycobacterium smegmatis-infected fish macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48847-1
Abstract: The implications of TLR-2 mediated alterations in cytosolic-Ca2+((Ca2+)c) levels in M. smegmatis infections is not well known. Using headkidney macrophages (HKM) from Clarias gariepinus, we observed TLR-2 signalling is required in the phagocytosis of M.… read more here.
Keywords: production; apoptosis; ca2 surge; tnf production ... See more keywords
Transcriptional and post‐translational regulation of AccD6 in Mycobacterium smegmatis
Sign Up to like & getrecommendations! Published in 2018 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fny074
Abstract: &NA; AccD6 is an important component of acetyl‐CoA/propionyl‐CoA carboxylase, which acts as a key role in mycolic acid synthesis and short chain fatty acyl‐coenzyme A metabolism. In this study, we demonstrated that AccD6 of Mycobacterium… read more here.
Keywords: post translational; accd6 mycobacterium; transcriptional post; coa ... See more keywords
Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro‐inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000511
Abstract: Purpose. The DosR/DosS two‐component regulatory system of Mycobacterium tuberculosis regulates the expression of numerous genes under stress conditions and is important for the long‐term survival of M. tuberculosis in the host. The rv2626c gene of… read more here.
Keywords: protein; mycobacterium; response; rv2626c ... See more keywords
Nudix hydrolases with Coenzyme A (CoA) and acyl-CoA pyrophosphatase activities confer growth advantage to Mycobacterium smegmatis.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology"
DOI: 10.1099/mic.0.000850
Abstract: Nudix hydrolase family proteins hydrolyse toxic by-products of cellular metabolism such as mutagenic nucleoside triphosphates, sugar nucleotides and signalling molecules. We studied the substrate specificities of Nudix hydrolases encoded by rv3672c and rv3040c from Mycobacterium… read more here.
Keywords: nudix hydrolases; msmeg; coa; coa pyrophosphatase ... See more keywords
Crystal structure and acetylation of BioQ suggests a novel regulatory switch for biotin biosynthesis in Mycobacterium smegmatis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.14066
Abstract: Biotin (vitamin B7), a sulfur‐containing fatty acid derivative, is a nutritional virulence factor in certain mycobacterial species. Tight regulation of biotin biosynthesis is important because production of biotin is an energetically expensive process requiring 15–20… read more here.
Keywords: acetylation; biotin; bioq; biotin biosynthesis ... See more keywords