SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13343
Abstract: Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed… read more here.
Keywords: nonsense mediated; smg1; decay nmd; mrna decay ... See more keywords
Abstract A16: Suppressor of morphogenesis in genitalia 1 (SMG1) is a novel negative regulator of mammalian target of rapamycin complex 2 (mTORC2)
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DOI: 10.1158/1557-3125.pi3k-mtor18-a16
Abstract: SMG1 is a member of the PI-3 kinase-like kinase family of proteins, which includes ataxia telangiectasia mutated (ATM), Dna-dependent protein kinase (DNA-PK) and mTOR. Our previous work demonstrated that SMG1 loss in mice increased cancer… read more here.
Keywords: kinase; mtorc2; mtor; phosphorylation ... See more keywords
A Novel Role of SMG1 in Cholesterol Homeostasis That Depends Partially on p53 Alternative Splicing
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DOI: 10.3390/cancers14133255
Abstract: Simple Summary p53 isoforms have been reported in various tumor types. Both p53β and p53γ were recently reported to retain functionalities of full-length p53α. A role for p53 and p53 loss in cholesterol metabolism has… read more here.
Keywords: smg1; inhibition; mcf7; p53 p53 ... See more keywords