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   Articles with "smn" as a keyword



Integrated Bilayer Microneedle Dressing and Triboelectric Nanogenerator for Intelligent Management of Infected Wounds

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recommendations! Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202316820

Abstract: The integration of real‐time monitoring and on‐demand treatment has substantial potential to accelerate wound healing processes. In this context, versatile bilayer microneedles (MNs) and a triboelectric nanogenerator (TENG) are developed as a theranostic platform for… read more here.

Keywords: smn; triboelectric nanogenerator; integrated bilayer; management ... See more keywords

The authors reply: Letter on: "Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy" by Zhou et al.

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recommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"

DOI: 10.1002/jcsm.12608

Abstract: We would like to thank the comments from Dr Chen on our paper on ‘Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy’. In this study, we combined the survival… read more here.

Keywords: myostatin; muscle; smn; myostatin inhibition ... See more keywords

Spinal motor neurons and motor function in older adults

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recommendations! Published in 2018 at "Journal of Neurology"

DOI: 10.1007/s00415-018-9118-y

Abstract: This study examined the relation between lumbar spinal motor neuron (SMN) indices and motor function proximate to death in community-dwelling older adults. Older adults (N = 145) participating in the Rush Memory and Aging Project underwent structured… read more here.

Keywords: death; motor neurons; smn; spinal motor ... See more keywords

SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities

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recommendations! Published in 2017 at "Human Genetics"

DOI: 10.1007/s00439-017-1835-2

Abstract: Low levels of the survival of motor neuron (SMN) protein cause the neurodegenerative disease spinal muscular atrophy (SMA). SMA is a pediatric disease characterized by spinal motor neuron degeneration. SMA exhibits several levels of severity… read more here.

Keywords: response; smn protein; smn; disease ... See more keywords

Mislocalization of SMN from the I-band and M-band in human skeletal myofibers in spinal muscular atrophy associates with primary structural alterations of the sarcomere

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recommendations! Published in 2020 at "Cell and Tissue Research"

DOI: 10.1007/s00441-020-03236-3

Abstract: Spinal muscular atrophy (SMA) is caused by a deletion or mutation of the survival motor neuron 1 (SMN1) gene. Reduced SMN levels lead to motor neuron degeneration and muscular atrophy. SMN protein localizes to the… read more here.

Keywords: skeletal myofibers; smn; spinal muscular; band ... See more keywords

SMA mutations in SMN Tudor and C-terminal domains destabilize the protein

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recommendations! Published in 2017 at "Brain and Development"

DOI: 10.1016/j.braindev.2017.03.002

Abstract: BACKGROUND AND PURPOSE Most spinal muscular atrophy (SMA) patients are homozygous for survival of motor neuron 1 gene (SMN1) deletion. However, some SMA patients carry an intragenic SMN1 mutation. Such patients provide a clue to… read more here.

Keywords: smn1; sma patients; mutations smn; smn ... See more keywords

TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109277

Abstract: The activity of the SMN complex in promoting the assembly of pre-mRNA processing UsnRNPs correlates with condensation of the complex in nuclear Cajal bodies. While mechanistic details of its activity have been elucidated, the molecular… read more here.

Keywords: phase separation; liquid phase; smn complex; smn ... See more keywords

Abnormal functional network connectivity mediates the relationship between depressive symptoms and cognitive decline in late-onset depression

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recommendations! Published in 2025 at "Psychological Medicine"

DOI: 10.1017/s0033291725100706

Abstract: Abstract Background Late-onset depression (LOD) is featured by disrupted cognitive performance, which is refractory to conventional treatments and increases the risk of dementia. Aberrant functional connectivity among various brain regions has been reported in LOD,… read more here.

Keywords: smn; functional network; depression; connectivity ... See more keywords

Arginine methylation-dependent METTL14-SMN interaction regulates RNA m6A homeostasis

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recommendations! Published in 2025 at "EMBO Reports"

DOI: 10.1038/s44319-025-00590-7

Abstract: N6-methyladenosine (m6A) homeostasis is essential for development, and its dysregulation is linked to cancers and neurological disorders. However, the mechanisms regulating m6A remain unclear. Here, we identify the survival of motoneuron (SMN) protein as a… read more here.

Keywords: arginine methylation; m6a homeostasis; methylation; smn ... See more keywords

SMN Enhances Pluripotent Genes Expression and Facilitates Cell Reprogramming.

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recommendations! Published in 2022 at "Stem cells and development"

DOI: 10.1089/scd.2022.0091

Abstract: Survival motor neuron (SMN) plays important roles in snRNPs assembly and mRNA splicing. Deficiency of SMN causes spinal muscular atrophy (SMA), a leading genetic disease of childhood mortality. Previous studies have shown that SMN regulates… read more here.

Keywords: smn enhances; pluripotent genes; expression; smn ... See more keywords
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Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons

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recommendations! Published in 2019 at "Brain"

DOI: 10.1093/brain/awy330

Abstract: The molecular mechanisms responsible for selective motor neuron loss in SMA remain elusive. Rizzo et al. show that deregulated transcripts in SMA-motor neurons share motif 7, targeted by SYNCRIP, which binds SMN. Impaired SYNCRIP-SMN interaction… read more here.

Keywords: motor neurons; smn; rna; motor ... See more keywords