Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0773-8
Abstract: BackgroundMedulloblastoma (MB) is the most common malignant brain tumour in children but also rarely occur in adults. Sonic Hedgehog (SHH) driven MB is associated with aberrant activation of the SHH signalling pathway. SMO inhibitors, sonidegib… read more here.
Keywords: phase; sonidegib; shh driven; treatment ... See more keywords
Targeting the Hedgehog Pathway in Rhabdomyosarcoma
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DOI: 10.3390/cancers15030727
Abstract: Simple Summary In the first sections of this review, we provide a comprehensive description of the Hedgehog signalling pathway in mammals and the main general models of pathway activation. Subsequently, the review focuses on the… read more here.
Keywords: hedgehog pathway; targeting hedgehog; smo inhibitors; pathway rhabdomyosarcoma ... See more keywords