Endothelial‐Smooth Muscle Cell Interactions in a Shear‐Exposed Intimal Hyperplasia on‐a‐Dish Model to Evaluate Therapeutic Strategies
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DOI: 10.1002/advs.202202317
Abstract: Intimal hyperplasia (IH) represents a major challenge following cardiovascular interventions. While mechanisms are poorly understood, the inefficient preventive methods incentivize the search for novel therapies. A vessel‐on‐a‐dish platform is presented, consisting of direct‐contact cocultures with… read more here.
Keywords: endothelial smooth; intimal hyperplasia; smooth muscle; model ... See more keywords
Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation
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DOI: 10.1002/advs.202203995
Abstract: Vascular smooth muscle cells (SMCs) can adapt to changes in cellular geometric cues; however, the underlying mechanisms remain elusive. Using 2D micropatterned substrates to engineer cell geometry, it is found that in comparison with an… read more here.
Keywords: dna; muscle cells; geometry; vascular smooth ... See more keywords
Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis
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DOI: 10.1002/advs.202204038
Abstract: Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is a pore‐forming effector of pyroptosis. In this study, the role of… read more here.
Keywords: muscle cells; abdominal aortic; vascular smooth; aortic aneurysm ... See more keywords
Npom‐Protected NONOate Enables Light‐Triggered NO/cGMP Signalling in Primary Vascular Smooth Muscle Cells
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DOI: 10.1002/cbic.201700683
Abstract: Diazeniumdiolates (NONOates) are a class of nitric‐oxide‐releasing substances widely used in studies of NO/cGMP signalling. Because spatiotemporal control is highly desirable for such purposes, we have synthesised a new Npom‐caged pyrrolidine NONOate. A kinetic analysis… read more here.
Keywords: vascular smooth; cgmp signalling; muscle cells; npom protected ... See more keywords
TRPC3 overexpression and intervention in airway smooth muscle of ovalbumin‐induced hyperresponsiveness and remodeling
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DOI: 10.1002/cbin.10970
Abstract: Transient receptor potential canonical channel 3 (TRPC3) proteins function as non‐voltage‐gated Ca2+‐permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression… read more here.
Keywords: trpc3; hyperresponsiveness remodeling; smooth muscle; mice ... See more keywords
Polarization, migration, and homotypical interactions among prostatic smooth muscle cells in a laminin 111‐rich extracellular matrix
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DOI: 10.1002/cbin.11535
Abstract: Prostate cancer is a life‐threatening condition worldwide. As the tumor progresses, smooth muscle cells (SMCs) become atrophic/dedifferentiated, within a series of stromal changes named stromal reaction. Here, we tested whether a laminin 111‐rich extracellular matrix… read more here.
Keywords: microscopy; muscle cells; laminin 111; smooth muscle ... See more keywords
Cell-To-Cell Communication in the Resistance Vasculature.
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DOI: 10.1002/cphy.c210040
Abstract: The arterial vasculature can be divided into large conduit arteries, intermediate contractile arteries, resistance arteries, arterioles, and capillaries. Resistance arteries and arterioles primarily function to control systemic blood pressure. The resistance arteries are composed of… read more here.
Keywords: cell; muscle cells; resistance; vasculature ... See more keywords
HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA‐520d‐3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm
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DOI: 10.1002/ehf2.13968
Abstract: Recently, long non‐coding RNAs (lncRNAs) have been revealed to mediate smooth muscle dysfunction in thoracic aortic aneurysm (TAA). LncRNA HOXA‐AS2 has been proposed to engage in the regulation of diverse diseases. However, its function in… read more here.
Keywords: hoxa; growth; thoracic aortic; aortic aneurysm ... See more keywords
Chemical imaging of fresh vascular smooth muscle cell response by epi-detected stimulated Raman scattering.
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DOI: 10.1002/jbio.201700005
Abstract: An understanding of deformation of cardiovascular tissue under hemodynamic load is crucial for understanding the health and disease of blood vessels. In the present work, an epi-detected stimulated Raman scattering (epi-SRS) imaging platform was designed… read more here.
Keywords: raman scattering; detected stimulated; stimulated raman; vascular smooth ... See more keywords
Linear ubiquitination modification of NR6A1 by LUBAC inhibits RIPK3 kinase activity and attenuates apoptosis of vascular smooth muscle cells
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DOI: 10.1002/jbt.23091
Abstract: Nuclear receptor subfamily 6 group A member 1 (NR6A1) is involved in promoting the apoptotic process of vascular smooth muscle cells (VSMCs) which is a critical process involved in atherosclerosis, but the action mechanism remains… read more here.
Keywords: lubac; apoptosis; muscle cells; vascular smooth ... See more keywords
The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: An in vivo and in vitro analysis
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DOI: 10.1002/jcb.29272
Abstract: In this study, we established both an animal model and a cellular model of hyperuricemia (HUC). Subsequently, we treated these models with allopurinol (ALLO) to study the effect of uric acid (UA) and ALLO on… read more here.
Keywords: osteoblasts vascular; vascular smooth; muscle cells; proliferation osteoblasts ... See more keywords