Smoothelin-like 1 knockout mice display sex-dependent alterations in blood flow and cardiac function.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0172
Abstract: Smoothelin-like 1 (SMTNL1) modulates the contractile performance of smooth muscle and thus has a key role in vascular homeostasis. Elevated vascular tone, recognized as a contributor to the development of progressive cardiac dysfunction, was previously… read more here.
Keywords: function; smtnl1; knockout; mice ... See more keywords
Abstract 244: Post- But Not Pre-menopausal Female Smoothelin-like 1 Deficient Mice Develop Diastolic Dysfunction Unlike Their Male Counterparts
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.244
Abstract: Diastolic dysfunction is a core characteristic of heart failure with preserved ejection fraction (HFpEF), which accounts for half of all HF cases. Our group revealed a novel impact of the smoothelin-like 1 (SMTNL1) protein which… read more here.
Keywords: mice develop; smoothelin like; mice; female mice ... See more keywords
Smoothelin-Like Protein 1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.751488
Abstract: Hyperthyroidism triggers a glycolytic shift in skeletal muscle (SKM) by altering the expression of metabolic proteins, which is often accompanied by peripheral insulin resistance. Our previous results show that smoothelin-like protein 1 (SMTNL1), a transcriptional… read more here.
Keywords: skeletal muscle; hyperthyroidism; smtnl1; like protein ... See more keywords