Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.04.067
Abstract: Sphingomyelin synthase (SMS) is a membrane enzyme that catalyzes the synthesis of sphingomyelin, is required for the maintenance of plasma membrane microdomain fluidity, and has two isoforms: SMS1 and SMS2. Although these isoforms exhibit the… read more here.
Keywords: sms2 inhibitors; sms2; sphingomyelin synthase; sphingomyelin ... See more keywords
GPRC5B-Mediated Sphingomyelin Synthase 2 Phosphorylation Plays a Critical Role in Insulin Resistance
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DOI: 10.1016/j.isci.2018.10.001
Abstract: Summary GPRC5B recruitment of Src family kinases has been implicated in diet-induced insulin resistance. However, the mechanism of this action is not fully understood. Here, we report that GPRC5B-mediated phosphorylation of sphingomyelin synthase 2 (SMS2)… read more here.
Keywords: insulin; gprc5b; insulin resistance; sms2 ... See more keywords
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.02.486804
Abstract: Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamental… read more here.
Keywords: sphingomyelin synthase; sms2; sms2 variants; secretory pathway ... See more keywords