Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.
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DOI: 10.1016/j.ejmech.2017.04.067
Abstract: Sphingomyelin synthase (SMS) is a membrane enzyme that catalyzes the synthesis of sphingomyelin, is required for the maintenance of plasma membrane microdomain fluidity, and has two isoforms: SMS1 and SMS2. Although these isoforms exhibit the… read more here.
Keywords: sms2 inhibitors; sms2; sphingomyelin synthase; sphingomyelin ... See more keywords