Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0485-1
Abstract: Glioblastoma, one of the common malignant brain tumors, results in the highly death, but its underlying molecular mechanisms remain unclear. Smurf1, a member of Nedd4 family of HECT-type ligases, has been reported to contribute to… read more here.
Keywords: suppression smurf1; smurf1; glioma; expression ... See more keywords
Hippo kinase NDR2 inhibits IL‐17 signaling by promoting Smurf1‐mediated MEKK2 ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.10.005
Abstract: HighlightsNDR2 knockdown promotes IL‐17‐induced inflammation by activation of ERK, p38 and NF‐&kgr;B.NDR2 interacts with Smurf1 and MEKK2, and promotes Smurf1‐mediated k48‐linked ubiquitination of MEKK2.MEKK2 positively regulates IL‐17‐induced inflammation while Smurf1 negatively regulates IL‐17‐induced inflammation. Abstract… read more here.
Keywords: smurf1; mekk2 ubiquitination; inflammation; promoting smurf1 ... See more keywords
FOSL1 promotes tumorigenesis in colorectal carcinoma by mediating the FBXL2/Wnt/β-catenin axis via Smurf1.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105405
Abstract: Colorectal carcinoma (CC), one of the most prevalent digestive cancers with high mortality and morbidity globally, still lacks powerful therapies to improve the prognosis. Here, we established that the expression of fos-like antigen-1 (Fosl1) was… read more here.
Keywords: fosl1; smurf1; wnt catenin; colorectal carcinoma ... See more keywords
miR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2024335
Abstract: ABSTRACT Chronic heart failure (CHF) is a prevalent health concern with complex pathogenesis. This current study set out to estimate the function of the miR-129-5p/Smurf1/PTEN axis on cardiac function injury in CHF. The model of… read more here.
Keywords: smurf1; function; cardiac function; pten expression ... See more keywords
Smurf1 regulates ameloblast polarization by ubiquitination‐mediated degradation of RhoA
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13387
Abstract: Cell polarity is essential for ameloblast differentiation and enamel formation. Smurf1 can mediate cell polarization through ubiquitination degradation of specific substrates. But it remains unclear whether Smurf1 could regulate ameloblast polarity and the underlying mechanism.… read more here.
Keywords: smurf1; cell; rhoa; polarization ... See more keywords
miR-154-5p Affects the TGFβ1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7502632
Abstract: Aim The study is aimed at verifying miR-154-5p and Smurf1 combination in glomerular mesangial cells regulating TGFβ1/Smad3 pathway-related protein ubiquitination in the model of diabetic rats renal tissues, primary mesangial cells, and cell lines. Methods… read more here.
Keywords: tgf smad3; smurf1; mir 154; diabetic kidney ... See more keywords
ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202101330
Abstract: The research uncovers a non-canonical role of ERK in TGF-beta-induced EMT, revealing ERK-mediated phosphorylation of Smurf1 is required for its sufficient binding to RhoA and the subsequent RhoA turnover. Epithelial-mesenchymal transition (EMT) has fundamental roles… read more here.
Keywords: metastasis; smurf1; rhoa; erk ... See more keywords
Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10020229
Abstract: SMAD ubiquitination regulatory factor 1 (Smurf1) is a Nedd4 family E3 ubiquitin ligase that regulates cell motility, polarity and TGFβ signaling. Smurf1 contains an N-terminal protein kinase C conserved 2 (C2) domain that targets cell… read more here.
Keywords: smurf1; ubiquitin ligase; membrane; domain ... See more keywords