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   Articles with "smurf2" as a keyword



MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12581

Abstract: SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I. However, the… read more here.

Keywords: 195 mir; mir 195; mir 497; smurf2 ... See more keywords

LncRNA FIRRE stimulates PTBP1‐induced Smurf2 decay, stabilizes B‐cell receptor, and promotes the development of diffuse large B‐cell lymphoma

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recommendations! Published in 2022 at "Hematological Oncology"

DOI: 10.1002/hon.3004

Abstract: Sustained expression of B‐cell receptor (BCR) critically contributes to the development of diffuse large B‐cell lymphoma (DLBCL). However, little is known on the mechanism regulating BCR expression. In the present study, we explored the biological… read more here.

Keywords: cell; development; dlbcl; decay ... See more keywords

Smurf2 Suppresses Proliferation and Cell Cycle of Triple‐Negative Breast Cancer Cells by Promoting the Polyubiquitination and Degradation of RPL35A

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recommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.70394

Abstract: Human L35a ribosomal protein (RPL35A) has been reported to confer higher drug resistance and viability to triple‐negative breast cancer (TNBC) cells, but the mechanism related to its promotion of TNBC malignant progression is still unclear.… read more here.

Keywords: smurf2; rpl35a; negative breast; triple negative ... See more keywords

FOXA2/miR-148a-3p/SMURF2 signaling feed-forward loop alleviates spinal cord ischemia-reperfusion injury-induced neuropathic pain by modulating microglia polarization in rats

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1563377

Abstract: Background Microglia polarization is crucial in mediating neuropathic pain. However, the role of microglia polarization in regulating spinal cord ischemia-reperfusion injury (SCIRI)-induced neuropathic pain is largely unknown. This study aimed to elucidate the relationship between… read more here.

Keywords: smurf2; microglia polarization; mir 148a; neuropathic pain ... See more keywords

The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and Tissues

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14071607

Abstract: Simple Summary KAP1 plays an essential role in different molecular and cellular processes central to carcinogenesis, disease progression, and treatment response, revealing both tumor promoting and anticancer functions. The mechanisms that control the steady-state levels… read more here.

Keywords: role; smurf2; kap1; ubiquitin ligase ... See more keywords