Hakai, a novel Runx2 interacting protein, augments osteoblast differentiation by rescuing Runx2 from Smurf2‐mediated proteasome degradation
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DOI: 10.1002/jcp.31388
Abstract: Runt‐related transcription factor 2 (Runx2) is a key regulator of osteoblast differentiation and bone formation. In Runx2‐deficient embryos, skeletal development ceases at the cartilage anlage stage. These embryos die of respiratory failure upon birth and… read more here.
Keywords: smurf2 mediated; hakai; degradation; osteoblast differentiation ... See more keywords