The efficacy and safety of reduced-dose sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with rheumatic diseases
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DOI: 10.1080/14397595.2020.1812834
Abstract: Abstract Objectives Pneumocystis pneumonia (PCP) is a life-threatening opportunistic infection. Sulfamethoxazole-trimethoprim (SMX/TMP) is the first-line drug for PCP prophylaxis. However, adverse events (AEs) force clinicians to alter or reduce the drug dosage. Methods We retrospectively… read more here.
Keywords: pcp; patients rheumatic; group; smx tmp ... See more keywords
145. the Efficacy and Safety of Low Dose Trimethoprim-sulfamethoxazole for the Treatment of Pneumocystis Pneumonia: A Systematic Review and Meta-analysis
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DOI: 10.1093/ofid/ofaa439.455
Abstract: Pneumocystis jirovecii pneumonia (PJP) is an opportunistic fungal infection causing significant morbidity and mortality in immunocompromised patients. The conventional treatment of PJP is sulfamethoxazole-trimethoprim (SMX-TMP) dosed at 15–20 mg/kg/day of the trimethoprim component. This high-dose… read more here.
Keywords: low dose; treatment; mortality; smx tmp ... See more keywords
Adherence to recent antibiotic guidelines for acute uncomplicated cystitis
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DOI: 10.1097/jxx.0000000000000526
Abstract: Supplemental Digital Content is Available in the Text. ABSTRACT Background: In 2017, the Centers for Disease Control and Prevention (CDC) published guidelines for treating acute uncomplicated cystitis (AUC) with nitrofurantoin (NTF), sulfamethoxazole-trimethoprim (SMX-TMP), or fosfomycin… read more here.
Keywords: antibiotic resistance; smx tmp; adherence recent; uncomplicated cystitis ... See more keywords
Application of Rank Annihilation Factor Analysis for Antibacterial Drugs Determination by Means of pH Gradual Change-UV Spectral Data
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DOI: 10.3390/antibiotics9070383
Abstract: The main objective of this study was to develop a simple and efficient spectrophotometric technique combined with chemometrics for the simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP) in drug formulations. Specifically, we sought: (i)… read more here.
Keywords: annihilation factor; determination; factor analysis; rank annihilation ... See more keywords
Indirect Photodegradation of Sulfamethoxazole and Trimethoprim by Hydroxyl Radicals in Aquatic Environment: Mechanisms, Transformation Products and Eco-Toxicity Evaluation
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DOI: 10.3390/ijms21176276
Abstract: The bacteriostatic antibiotics, sulfamethoxazole (SMX) and trimethoprim (TMP), have frequently been found in wastewater and surface water, which raises the concerns about their ecotoxicological effects. The indirect photochemical transformation has been proven to be an… read more here.
Keywords: eco toxicity; transformation products; transformation; smx tmp ... See more keywords