Smyd3-associated regulatory pathways in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2016.08.008
Abstract: SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the increased expression of which correlates with poor prognosis in various types of cancer. In liver and colon tumors, SMYD3 is localized in… read more here.
Keywords: smyd3; cancer smyd3; associated regulatory; smyd3 associated ... See more keywords
Clinicopathological and Prognostic Significance of SMYD3 in Human Cancers: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2021.0199
Abstract: Background: Dysregulation of the SET and MYND domain-containing protein 3 (SMYD3) has been found in multiple cancers. This meta-analysis aimed to elucidate the association between SMYD3 expression and clinical outcomes in cancer. Methods: A systematic… read more here.
Keywords: meta analysis; smyd3 expression; smyd3; analysis ... See more keywords
SMYD3 promotes epithelial ovarian cancer metastasis by down-regulating p53 protein stability and promoting p53 ubiquitination.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz078
Abstract: Epithelial ovarian cancer (EOC) has a very poor prognosis because of tumor invasiveness. Here, we reported that SMYD3 a lysine methyltransferase was frequently upregulated in EOC and associated with poor prognosis. A series of in… read more here.
Keywords: smyd3; epithelial ovarian; p53 protein; metastasis ... See more keywords
Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1646
Abstract: SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase (PKMT) which was initially described as H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has recently been reported to methylate and regulate several non-histone… read more here.
Keywords: smyd3; inhibitor; bay 6035; benzodiazepine based ... See more keywords
Abstract 2320: Dissecting the effects of Smyd3 depletion in the tumor microenvironment of HPV-negative head and neck squamous cell carcinoma mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2320
Abstract: Human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) patients have a poor prognosis and most patients with metastatic disease are resistant to pembrolizumab. We recently showed that depletion of SET and MYND… read more here.
Keywords: hpv negative; cell; smyd3; smyd3 asos ... See more keywords
SMYD3 Promotes Cell Cycle Progression by Inducing Cyclin D3 Transcription and Stabilizing the Cyclin D1 Protein in Medulloblastoma
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DOI: 10.3390/cancers14071673
Abstract: Simple Summary Medulloblastoma is the most common malignant pediatric brain tumor and is classified into four molecular subgroups: Wnt, Shh, Group 3, and Group 4. Of these subgroups, patients with Myc+ Group 3 MB have… read more here.
Keywords: cyclin protein; smyd3; cycle progression; cell cycle ... See more keywords
Hit identification of SMYD3 enzyme inhibitors using structure-based pharmacophore modeling.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0462
Abstract: Aim: SMYD3 enzyme is overexpressed in many types of cancer and its role in the methylation of cytoplasmic mitogen-activated protein kinase, kinase kinase 2 (MAP3K2), has been linked to promotion of Kras-driven cancer in pancreatic… read more here.
Keywords: smyd3; structure based; based pharmacophore; smyd3 enzyme ... See more keywords
ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastric Cancer"
DOI: 10.5230/jgc.2017.17.e33
Abstract: Purpose We previously found that the histone methyltransferase suppressor of variegation, enhancer of zeste, trithorax and myeloid-nervy-deformed epidermal autoregulatory factor-1 domain-containing protein 3 (SMYD3) is a potential independent predictive factor or prognostic factor for overall… read more here.
Keywords: smyd3; gastric cancer; proliferation; migration ... See more keywords