Smyd3-associated regulatory pathways in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2016.08.008
Abstract: SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the increased expression of which correlates with poor prognosis in various types of cancer. In liver and colon tumors, SMYD3 is localized in… read more here.
Keywords: smyd3; cancer smyd3; associated regulatory; smyd3 associated ... See more keywords
Clinicopathological and Prognostic Significance of SMYD3 in Human Cancers: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2021.0199
Abstract: Background: Dysregulation of the SET and MYND domain-containing protein 3 (SMYD3) has been found in multiple cancers. This meta-analysis aimed to elucidate the association between SMYD3 expression and clinical outcomes in cancer. Methods: A systematic… read more here.
Keywords: meta analysis; smyd3 expression; smyd3; analysis ... See more keywords
SMYD3 promotes epithelial ovarian cancer metastasis by down-regulating p53 protein stability and promoting p53 ubiquitination.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz078
Abstract: Epithelial ovarian cancer (EOC) has a very poor prognosis because of tumor invasiveness. Here, we reported that SMYD3 a lysine methyltransferase was frequently upregulated in EOC and associated with poor prognosis. A series of in… read more here.
Keywords: smyd3; epithelial ovarian; p53 protein; metastasis ... See more keywords
SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-2117
Abstract: The development of BCR-ABL tyrosine kinase inhibitors (TKIs) has revolutionized disease management of chronic myeloid leukemia (CML). However, the persistence of leukemia stem cells (LSCs) remains a major barrier to curing CML, highlighting the urgent… read more here.
Keywords: leukemia stem; lscs; stem cells; smyd3 ... See more keywords
Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1646
Abstract: SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase (PKMT) which was initially described as H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has recently been reported to methylate and regulate several non-histone… read more here.
Keywords: smyd3; inhibitor; bay 6035; benzodiazepine based ... See more keywords
Abstract 2320: Dissecting the effects of Smyd3 depletion in the tumor microenvironment of HPV-negative head and neck squamous cell carcinoma mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2320
Abstract: Human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) patients have a poor prognosis and most patients with metastatic disease are resistant to pembrolizumab. We recently showed that depletion of SET and MYND… read more here.
Keywords: hpv negative; cell; smyd3; smyd3 asos ... See more keywords
Abstract 1734: Dissecting the bifaceted function of SMYD3 as a transcriptional activator and repressor in HPV-negative HNSCC
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1734
Abstract: Background: Approximately 75% of Human-papilloma-virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) tumors carry genetic and expression alterations in the family of protein methyltransferases and demethylases, underscoring the importance of these enzymes in the… read more here.
Keywords: negative hnscc; function; hpv negative; smyd3 ... See more keywords
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-07072-3
Abstract: Adaptive thermogenesis driven by brown/beige adipose tissue has gained attention as a promising strategy for combating obesity. Histone methyltransferase SET and MYND Domain Containing 3 (Smyd3) is strongly associated with metabolic and cardiovascular diseases, however,… read more here.
Keywords: thermogenesis; smyd3; expression; wat browning ... See more keywords
Overexpression of SMYD3 Promotes Autosomal Dominant Polycystic Kidney Disease by Mediating Cell Proliferation and Genome Instability
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12030603
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder worldwide and progresses to end-stage renal disease (ESRD). However, its precise mechanism is not fully understood. In recent years, epigenetic reprogramming has… read more here.
Keywords: disease; dominant polycystic; smyd3; polycystic kidney ... See more keywords
SMYD3 Promotes Cell Cycle Progression by Inducing Cyclin D3 Transcription and Stabilizing the Cyclin D1 Protein in Medulloblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071673
Abstract: Simple Summary Medulloblastoma is the most common malignant pediatric brain tumor and is classified into four molecular subgroups: Wnt, Shh, Group 3, and Group 4. Of these subgroups, patients with Myc+ Group 3 MB have… read more here.
Keywords: cyclin protein; smyd3; cycle progression; cell cycle ... See more keywords
Hit identification of SMYD3 enzyme inhibitors using structure-based pharmacophore modeling.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0462
Abstract: Aim: SMYD3 enzyme is overexpressed in many types of cancer and its role in the methylation of cytoplasmic mitogen-activated protein kinase, kinase kinase 2 (MAP3K2), has been linked to promotion of Kras-driven cancer in pancreatic… read more here.
Keywords: smyd3; structure based; based pharmacophore; smyd3 enzyme ... See more keywords