Hit identification of SMYD3 enzyme inhibitors using structure-based pharmacophore modeling.
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DOI: 10.4155/fmc-2018-0462
Abstract: Aim: SMYD3 enzyme is overexpressed in many types of cancer and its role in the methylation of cytoplasmic mitogen-activated protein kinase, kinase kinase 2 (MAP3K2), has been linked to promotion of Kras-driven cancer in pancreatic… read more here.
Keywords: smyd3; structure based; based pharmacophore; smyd3 enzyme ... See more keywords