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   Articles with "smyd5" as a keyword



SMYD5 acts as a potential biomarker for hepatocellular carcinoma.

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recommendations! Published in 2022 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2022.113076

Abstract: Determining the prognosis of patients remains a challenge due to the phenotypic and molecular diversities of hepatocellular carcinomas (HCC). We aimed to evaluate the role of SMYD5 in HCC. Wilcoxon signed-rank test and logistic regression… read more here.

Keywords: smyd5; hcc; potential biomarker; acts potential ... See more keywords

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

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recommendations! Published in 2024 at "Cell Research"

DOI: 10.1038/s41422-024-01013-3

Abstract: While lysine methylation is well-known for regulating gene expression transcriptionally, its implications in translation have been largely uncharted. Trimethylation at lysine 22 (K22me3) on RPL40, a core ribosomal protein located in the GTPase activation center… read more here.

Keywords: lysine methylation; translation; catalyzes rpl40; rpl40 k22me3 ... See more keywords

Unique SMYD5 Structure Revealed by AlphaFold Correlates with Its Functional Divergence

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recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12060783

Abstract: SMYD5 belongs to a special class of protein lysine methyltransferases with an MYND (Myeloid-Nervy-DEAF1) domain inserted into a SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) domain. Despite recent advances in its functional characterization, the… read more here.

Keywords: structure; smyd5; unique smyd5; smyd5 structure ... See more keywords

SMYD5-BRD4 Interaction Drives Hepatocellular Carcinoma Progression: A Combined in Silico and Experimental Analysis

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recommendations! Published in 2025 at "Pharmaceuticals"

DOI: 10.3390/ph18081105

Abstract: Background/Objectives: Hepatocellular carcinoma (LIHC) poses significant challenges due to limited targeted therapeutic options. This study investigates SMYD5, an oncogene implicated in the pathogenesis of LIHC, and its interaction with the BRD4 protein. Methods: We employed… read more here.

Keywords: smyd5 brd4; hepatocellular carcinoma; brd4 interaction; smyd5 ... See more keywords