Unraveling the Nature of the Catalytic Power of Fluoroacetate Dehalogenase
Sign Up to like & getrecommendations! Published in 2018 at "ChemCatChem"
DOI: 10.1002/cctc.201701517
Abstract: Fluoroacetate dehalogenase is able to cleavage a carbon–fluoride bond, the strongest carbon–halogen bond in nature, in a process initiated by a SN2 reaction. The role of the enzyme machinery and particularly of the halogen pocket… read more here.
Keywords: fluoroacetate dehalogenase; sn2 reaction; unraveling nature; reaction ... See more keywords
A real space picture of the role of steric effects in SN2 reactions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26834
Abstract: Within substitution reactions, the Bimolecular Nucleophilic Substitution (SN2) reaction mechanism is one of the most frequently found and studied ones. Among other factors, the easiness of the SN2 pathway is classically considered to be determined… read more here.
Keywords: space picture; sn2 reaction; steric effects; real space ... See more keywords
Stereo- and Regiospecific SN2′ Reaction of MBH Adducts with Isocyanoacetates: en Route to Transition-Metal-Free α-Allylation of Isocyanoacetates
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07581
Abstract: Herein, we report that under mild and transition-metal-free conditions an unprecedented and practical SN2′ reaction of Morita–Baylis–Hillman adducts with isocyanoacetates takes place in a stereo- and regiospecific manner. This reaction which tolerates a wide variety… read more here.
Keywords: sn2 reaction; reaction; metal free; transition metal ... See more keywords