Targeted Delivery of DNA Topoisomerase Inhibitor SN38 to Intracranial Tumors of Glioblastoma Using Sub‐5 Ultrafine Iron Oxide Nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102816
Abstract: Effectively delivering therapeutics for treating brain tumors is hindered by the physical and biological barriers in the brain. Even with the compromised blood–brain barrier and highly angiogenic blood–tumor barrier seen in glioblastoma (GBM), most drugs,… read more here.
Keywords: intracranial tumors; sub ultrafine; sn38; ultrafine iron ... See more keywords
Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2
Sign Up to like & getrecommendations! Published in 2017 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.4508
Abstract: The synthesis of water‐soluble SN38 derivatives is presented, and their stability in solutions used during drug development studies has been investigated. A preliminary study of mechanism of action of 9‐aminomethyl SN38 is presented. Using NMR… read more here.
Keywords: sn38; preliminary study; study mechanism; mechanism action ... See more keywords
Tuning the efficacy of esterase-activatable prodrug nanoparticles for the treatment of colorectal malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120705
Abstract: Colorectal cancer (CRC) is one of the most common and lethal human cancers, and the clinical outcomes remain unsatisfactory because of the lack of effective and safe therapeutic regimens. Here, we describe a practical and… read more here.
Keywords: sn38; efficacy; esterase activatable; esterase ... See more keywords
Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00247-y
Abstract: Dear Editor, The selection of linkers and payloads plays a crucial role in determining the therapeutic indices of antibody–drug conjugates (ADCs). Valine–citrulline (Val–Cit) coupled with a self-immolative ρ-aminobenzyl (PAB) spacer as a cleavable dipeptide linker,… read more here.
Keywords: hrs7; sn38; ptx; drug ... See more keywords
A multifunctional SN38-conjugated nanosystem for defeating myelosuppression and diarrhea induced by irinotecan in esophageal cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr06266a
Abstract: A combination of chemotherapy and phototherapy has been proposed as a promising treatment for esophageal cancer (EC). Irinotecan as a first-line treatment option is widely prescribed for metastatic EC, however, its clinical application is extremely… read more here.
Keywords: esophageal cancer; sn38; myelosuppression diarrhea;
Critical roles of linker length in determining the chemical and self-assembly stability of SN38 homodimeric nanoprodrugs.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale horizons"
DOI: 10.1039/d2nh00425a
Abstract: Homodimeric prodrug nanoassemblies (HDPNs) have been widely studied for efficient cancer therapy by virtue of their ultra-high drug loading and distinct nanostructure. However, the development of SN38 HDPNs is still a great challenge due to… read more here.
Keywords: sn38; assembly stability; self assembly; sn38 sn38 ... See more keywords
Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-3811
Abstract: Purpose: Currently, read more here.
Keywords: sn38; cpt; tocopherol oxyacetate; xenograft model ... See more keywords
Synthesis and biological evaluation of theranostic Trastuzumab-SN38 conjugate for Near-IR fluorescence imaging and targeted therapy of HER2+ breast cancer.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4345264
Abstract: Here, we report on the design, synthesis, and biological evaluation of a new theranostic antibody drug conjugate (ADC), Cy5-Ab-SS-SN38, that consists of the HER2-specific antibody trastuzumab (Ab) connected to the near infrared (NIR) pentamethine cyanine… read more here.
Keywords: synthesis biological; biological evaluation; her2; sn38 ... See more keywords
Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s173279
Abstract: Purpose A liposome-based siRNA–drug combination was evaluated as a potential therapeutic strategy to improve the curative effect. Methods A topoisomerase inhibitor SN38 prodrug was combined with a survivin siRNA through codelivery using transferrin (Tf)-L-SN38/P/siRNA. In… read more here.
Keywords: sn38; codelivery sn38; sn38 sirna; survivin sirna ... See more keywords
Cholesterol-Inulin Conjugates for Efficient SN38 Nuclear Delivery: Nanomedicines for Precision Cancer Therapy
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DOI: 10.3390/cancers14194857
Abstract: Simple Summary Severe limitations of conventional chemotherapy including unspecific biodistribution both at the tissue and cell organelle level have led to the necessity of developing precise and personalized therapeutic strategies. Accordingly, nanomedicine has aroused increased… read more here.
Keywords: precision; cell; sn38; inu cys ... See more keywords
Synthesis and Antitumor Evaluation of Biotin-SN38-Valproic Acid Conjugates
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093936
Abstract: Despite the strong anticancer activity of SN38 (7-ethyl-10-hydroxy-camptothecin), the severe side effects and loss of anticancer activity caused by the lack of selectivity to cancer cells and hydrolysis of ring E prevent its clinical application.… read more here.
Keywords: compound; sn38 valproic; biotin; sn38 ... See more keywords