Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2
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DOI: 10.1002/mrc.4508
Abstract: The synthesis of water‐soluble SN38 derivatives is presented, and their stability in solutions used during drug development studies has been investigated. A preliminary study of mechanism of action of 9‐aminomethyl SN38 is presented. Using NMR… read more here.
Keywords: sn38; preliminary study; study mechanism; mechanism action ... See more keywords