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   Articles with "snai1" as a keyword



PGC‐1α/SNAI1 axis regulates tumor growth and metastasis by targeting miR‐128b in gastric cancer

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28193

Abstract: Peroxisome proliferator‐activated receptor γ coactivator 1α (PGC‐1α) is a transcriptional coactivator that has been characterized as master regulators of mitochondrial biogenesis. It has been reported that aberrant regulation of PGC‐1α is involved in a variety… read more here.

Keywords: mir 128b; inhibition; expression; pgc ... See more keywords

Upregulation of Synuclein-γ and Snai1 Contributes to Poor Clinical Prognosis in Oral Squamous Cell Carcinoma Patients

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/6534626

Abstract: Synuclein-γ (SNCG) and Snai1 play an important role in the occurrence and development of different types of malignant tumors. However, the association between SNCG and Snai1 and the effect of their combination on oral squamous… read more here.

Keywords: expression sncg; snai1; oscc; sncg snai1 ... See more keywords

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood.2019002548

Abstract: Modulators of epithelial to mesenchymal transition (EMT) have recently emerged as novel players in the field of leukemia biology. The mechanisms by which EMT modulators contribute to leukemia pathogenesis, however, remain to be elucidated. Here… read more here.

Keywords: emt; pathogenesis; interaction; lsd1 ... See more keywords

Synergistic effects of ISL1 and KDM6B on non-alcoholic fatty liver disease through the regulation of SNAI1

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recommendations! Published in 2022 at "Molecular Medicine"

DOI: 10.1186/s10020-021-00428-7

Abstract: Background The increasing incidence of non-alcoholic fatty liver disease (NAFLD) has been reported worldwide, which urges understanding of its pathogenesis and development of more effective therapeutical methods for this chronic disease. In this study, we… read more here.

Keywords: isl1 kdm6b; kdm6b snai1; disease; snai1 ... See more keywords

Low Expression of SNAI1 in Lymph Node Metastasis Indicates Delayed Recurrence of Colonic Cancer

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recommendations! Published in 2022 at "AntiCancer Research"

DOI: 10.21873/anticanres.16102

Abstract: Background/Aim: Even though epithelial–mesenchymal transition markers in primary tumors are identified as a helpful indicator of cancer metastasis and prognosis, their expression in lymph node metastases (LNMs) remains poorly described. We aimed to investigate the… read more here.

Keywords: metastasis; expression snai1; snai1; expression ... See more keywords

A genome–wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs

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recommendations! Published in 2023 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2023.1110445

Abstract: The genome is pervasively transcribed to produce a vast array of non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides and are best known for their ability to regulate gene expression. Enhancer… read more here.

Keywords: crispr activation; genome wide; snai1; wide crispr ... See more keywords
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The Epithelial–Mesenchymal Transcription Factor SNAI1 Represses Transcription of the Tumor Suppressor miRNA let-7 in Cancer

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recommendations! Published in 2021 at "Cancers"

DOI: 10.3390/cancers13061469

Abstract: Simple Summary When cells undergo epithelial–mesenchymal transition (EMT) they gain characteristics of stem cells. We investigated the mechanism by which the EMT transcription factor SNAI1 induces stem cell features. In these studies, we observed that… read more here.

Keywords: stemness; transcription; cancer; let ... See more keywords

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

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recommendations! Published in 2021 at "eLife"

DOI: 10.7554/elife.66143

Abstract: The transcription factor Snai1, a well-known regulator of epithelial-to-mesenchymal transition, has been implicated in early cardiac morphogenesis as well as in cardiac valve formation. However, a role for Snai1 in regulating other aspects of cardiac… read more here.

Keywords: myocardial wall; intermediate filament; wall integrity; transcription factor ... See more keywords