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SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC

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1 Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.982821

Abstract: Triple-negative subtype of breast cancer (TNBC) is hallmarked by frequent disease relapse and shows highest mortality rate. Although PD-1/PD-L1 immune checkpoint blockades have recently shown promising clinical benefits, the overall response rate remains largely insufficient.… read more here.

Keywords: cd73; snai1 dependent; dependent upregulation; tnbc ... See more keywords