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   Articles with "snai2" as a keyword



The miR‐203/SNAI2 axis regulates prostate tumor growth, migration, angiogenesis and stemness potentially by modulating GSK‐3β/β‐CATENIN signal pathway

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recommendations! Published in 2018 at "IUBMB Life"

DOI: 10.1002/iub.1720

Abstract: Dysregulation of microRNA expression plays a pivotal role in the initiation and progression of a variety of human carcinomas including prostate cancer. Our previous studies have demonstrated that the silence of miR‐203 contributes to the… read more here.

Keywords: 203 snai2; mir 203; prostate cancer; snai2 ... See more keywords

A coherent FOXO3-SNAI2 feed-forward loop in autophagy

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2118285119

Abstract: Significance Understanding autophagy regulation is instrumental in developing therapeutic interventions for autophagy-associated disease. Here, we identified SNAI2 as a regulator of autophagy from a genome-wide screen in HeLa cells. Upon energy stress, SNAI2 is transcriptionally… read more here.

Keywords: snai2; feed forward; coherent foxo3; forward loop ... See more keywords

SNAI2 promotes the development of ovarian cancer through regulating ferroptosis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2021.2024319

Abstract: ABSTRACT This study aims to explore the regulatory mechanism of SNAI2 in ovarian cancer, and to uncover its correlation with ferroptosis. A human normal ovarian cell line IOSE-80 and four ovarian cancer cell lines (SKOV3,… read more here.

Keywords: cell; ovarian cancer; snai2; ferroptosis ... See more keywords

Abstract 1465: A SNAI2/CDKN1A pathway protects rhabdomyosarcoma tumors from radiation

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-1465

Abstract: Rhabdomyosarcoma (RMS) is tumor of the muscle and is the most common soft tissue cancer in children and teens, with approximately 400 to 500 new cases every year in the United States. There are two… read more here.

Keywords: snai2 cdkn1a; cdkn1a; snai2; tumors radiation ... See more keywords

Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition

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recommendations! Published in 2023 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2023.1188641

Abstract: Osteosarcomas are immune-resistant and metastatic as a result of elevated nonsense-mediated RNA decay (NMD), reactive oxygen species (ROS), and epithelial-to-mesenchymal transition (EMT). Although vitamin D has anti-cancer effects, its effectiveness and mechanism of action against… read more here.

Keywords: nonsense mediated; mesenchymal transition; snai2; mediated rna ... See more keywords

TRIM31 acts as an intermediate molecule in the process by which Snai2 impairs the proliferation of cervical cancer cells

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recommendations! Published in 2025 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2025.1537991

Abstract: Snai2 is a transcription factor that inhibits the proliferation of cervical cancer cells and tumor growth. The expression of Snai2 inhibited the expression of β-catenin and impaired Wnt/β-catenin signaling pathway activity. The results of the… read more here.

Keywords: proliferation cervical; cancer cells; cervical cancer; trim31 ... See more keywords

SNAI2 enhances HPV‑negative cervical cancer cell dormancy by modulating u‑PAR expression and the activity of the ERK/p38 signaling pathway in vitro

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recommendations! Published in 2024 at "Oncology Reports"

DOI: 10.3892/or.2024.8763

Abstract: The prognosis of patients with human papillomavirus (HPV)-negative cervical cancer is significantly worse than that of patients with HPV-positive cervical cancer. Understanding the mechanisms of this is crucial for preventing disease evolution. In the present… read more here.

Keywords: cancer; cervical cancer; cell; hpv negative ... See more keywords

Non-canonical signaling pathway of SNAI2 induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD10

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recommendations! Published in 2020 at "Theranostics"

DOI: 10.7150/thno.43198

Abstract: Background: Epithelial ovarian cancer (EOC) is one of the most lethal malignancies in women worldwide. Many studies showed the transcription factor SNAI2-induced Epithelial-Mesenchymal Transition (EMT) through inhibiting E-cadherin (E-cad) expression. Our previous study reported that… read more here.

Keywords: mir 222; transcription; snai2; pdcd10 ... See more keywords