Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12317
Abstract: Transcriptional regulation mediated by the zinc finger protein Snail1 controls early embryogenesis. By binding to the epithelial tumor suppressor CDH1 gene, Snail1 initiates the epithelial–mesenchymal transition (EMT). The EMT generates stem‐like cells and promotes invasiveness… read more here.
Keywords: negative breast; breast; snail1; breast cancer ... See more keywords
Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32376
Abstract: Myofibroblasts are a population of highly contractile fibroblasts that express and require the activity of the transcription factor Snail1. Cancer‐associated fibroblasts (CAFs) correlate with low survival of cancer patients when present in the stroma of… read more here.
Keywords: fibrosis; snail1; methyltransferase; myofibroblast ... See more keywords
Epithelial‐mesenchymal transition inducer Snail1 and invasive potential of intraductal breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.24708
Abstract: Transcription factor Snail1 is a key inducer of epithelial‐mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on… read more here.
Keywords: mesenchymal transition; inducer; snail1; epithelial mesenchymal ... See more keywords
LOXL3‐promoted hepatocellular carcinoma progression via promotion of Snail1/USP4‐mediated epithelial‐mesenchymal transition
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23617
Abstract: Lysyl‐oxidase‐like 3 (LOXL3) was reported to be essential in epithelial‐mesenchymal transition (EMT) of cancers. However, the role of LOXL3 in hepatocellular carcinoma (HCC) remained unclear. In this study, we explored clinical significance, biological functions, and… read more here.
Keywords: cell; hcc; usp4; snail1 ... See more keywords
The SNAIL1 promoter contains G-quadruplex structures regulating its gene expression and DNA replication.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112158
Abstract: SNAIL1 is a key regulator of epithelial-mesenchymal transition (EMT) and its expression is associated with tumor progression and poor clinical prognosis of cancer patients. Compared to the studies of SNAIL1 stability and its transcriptional regulation,… read more here.
Keywords: snail1 promoter; snail1; quadruplex structures; gene expression ... See more keywords
Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-017-0100-4
Abstract: Pancreatic cancer (PDAC) is one of the most dismal of human malignancies. Inhibiting or delaying the progression of precursor lesions of PDAC, pancreatic intraepthial neoplasia (PanINs), to invasive cancer, would be a major step. In… read more here.
Keywords: snail1; pancreatic injury; acinar ductal; lsl ... See more keywords
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation
Sign Up to like & getrecommendations! Published in 2023 at "EMBO reports"
DOI: 10.15252/embr.202254895
Abstract: Colon tumors of the mesenchymal subtype have the lowest overall survival. Snail1 is essential for the acquisition of this phenotype, characterized by increased tumor stemness and invasion, and high resistance to chemotherapy. Here, we find… read more here.
Keywords: snail1; tumor; colon tumor; noncanonical wnt ... See more keywords
Comparison of Snail1, ZEB1, E-Cadherin Expression Levels in HPV-Induced Cervical Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Public Health"
DOI: 10.18502/ijph.v49i11.4736
Abstract: Background: Molecular profiling techniques are the rapid detection of biomarkers in the human papillomavirus (HPV) infected cells. We aimed to measure the expression level of three cell factors including Snail1, ZEB-1, and E-cadherin in cervical… read more here.
Keywords: expression level; snail1; cervical cancer; expression ... See more keywords
USP27X, a new player on EMT and fibroblast activation
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26410
Abstract: The epithelial-mesenchymal transition (EMT) shifts epithelial cells towards a malignant mesenchymal phenotype, enhancing their invasiveness and chemoresistance. Cancer cells initiate an “EMT program” for their metastatic dissemination and this in turn is governed by several… read more here.
Keywords: emt; snail1; activation; cancer cells ... See more keywords
MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer"
DOI: 10.7150/jca.60008
Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and has a poor prognosis due to the high incidence of invasion and metastasis-related progression. However, the underlying mechanism remains elusive, and valuable… read more here.
Keywords: mst4; hcc; invasion; snail1 ... See more keywords