Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200574
Abstract: Uncontrolled bleeding from traumatic injury remains the leading cause of preventable death with loss of balance between blood clotting (coagulation) and blood clot breakdown (fibrinolysis). A major limitation of existing hemostatic agents is that they… read more here.
Keywords: blood; snake venom; uncontrolled bleeding; clot breakdown ... See more keywords
Identification evidence unraveled by strict proteomics rules toward forensic samples
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202200051
Abstract: Snake venom is a complex mixture of proteins and peptides secreted by venomous snakes from their poison glands. Although proteomics for snake venom composition, interspecific differences, and developmental evolution has been developed for a decade,… read more here.
Keywords: identification evidence; identification; unraveled strict; snake venom ... See more keywords
Leukocyte recruitment induced by snake venom metalloproteinases: Role of the catalytic domain.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.144
Abstract: Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory reactions after snakebites. This study aimed to investigate the effect of SVMP domains on the alterations in leukocyte-endothelium interactions in the microcirculation of mouse… read more here.
Keywords: catalytic domain; jar; venom metalloproteinases; leukocyte recruitment ... See more keywords
A novel synthetic peptide inspired on Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom active against multidrug-resistant clinical isolates.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.055
Abstract: Currently, the evolving and complex mechanisms of bacterial resistance to conventional antibiotics are increasing, while alternative medicines are drying up, which urges the need to discover novel agents able to kill antibiotic-resistant bacteria. Lys49 phospholipase… read more here.
Keywords: lys49 phospholipase; abyssus snake; oreganus abyssus; resistant clinical ... See more keywords
Effects of crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, on human endothelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.019
Abstract: Vascular endothelium plays an important modulatory role due to the production of molecules that mediate vasomotricity, inflammation, and leukocyte adhesion and rolling. Here we addressed whether crotoxin (25-200 μg/mL) - the main component of Crotalus durissus… read more here.
Keywords: crotoxin; durissus terrificus; endothelial cells; crotalus durissus ... See more keywords
Local and systemic effects of BtaMP-1, a new weakly hemorrhagic snake venom metalloproteinase purified from Bothriopsis taeniata snake venom.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.09.032
Abstract: A new weak hemorrhagic metalloproteinase named BtaMP-1 was purified from Bothriopsis taeniata snake venom by molecular exclusion followed by anion exchange chromatographies. This protein showed a molecular mass of 25,968.16 Da and is composed of 218… read more here.
Keywords: purified bothriopsis; bothriopsis taeniata; metalloproteinase; taeniata snake ... See more keywords
Biochemical and functional properties of a new l-amino acid oxidase (LAAO) from Micrurus lemniscatus snake venom
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biological Macromolecules"
DOI: 10.1016/j.ijbiomac.2019.11.033
Abstract: Abstract This study reports the purification of ML-LAAO, a new LAAO from the venom of Micrurus lemniscatus snake (ML-V), using size exclusion chromatography. ML-LAAO is a 69-kDa glycoprotein that represents ~2.0% of total venom proteins.… read more here.
Keywords: laao; lemniscatus snake; snake venom; micrurus lemniscatus ... See more keywords
Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2020.103863
Abstract: Proteomic characterization of Micrurus browni browni venom showed approximately 41 components belonging to 9 protein families, mainly phospholipases A2 (PLA2s) and three-finger toxins (3FTxs). Venom gland transcriptome yielded 39 venom transcripts belonging to 10 protein… read more here.
Keywords: venom; browni; coral snake; characterization ... See more keywords
Causes and Consequences of Snake Venom Variation
Sign Up to like & getrecommendations! Published in 2020 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2020.05.006
Abstract: Snake venoms are mixtures of toxins that vary extensively between and within snake species. This variability has serious consequences for the management of the world’s 1.8 million annual snakebite victims. Advances in ‘omic’ technologies have… read more here.
Keywords: variation; consequences snake; venom variation; causes consequences ... See more keywords
Pathophysiological significance and therapeutic applications of snake venom protease inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.03.011
Abstract: ABSTRACT Protease inhibitors are important constituents of snake venom and play important roles in the pathophysiology of snakebite. Recently, research on snake venom protease inhibitors has provided valuable information to decipher the molecular details of… read more here.
Keywords: protease; significance therapeutic; protease inhibitors; pathophysiological significance ... See more keywords
Citrus bioflavonoid, hesperetin, as inhibitor of two thrombin‐like snake venom serine proteases isolated from Crotalus simus
Sign Up to like & getrecommendations! Published in 2018 at "Toxicon"
DOI: 10.1016/j.toxicon.2018.01.005
Abstract: ABSTRACT Around 5.5 million people suffer from snakebites per year, with about 400,000 cases with some type of sequelae, such as amputation, and 20,000 to 125,000 cases with the fatal end. Usually, the victim outcome… read more here.
Keywords: thrombin like; serine proteases; inhibitor; crotalus simus ... See more keywords