N‐Substituted Nipecotic Acids as (S)‐SNAP‐5114 Analogues with Modified Lipophilic Domains
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DOI: 10.1002/cmdc.201900719
Abstract: Potential mGAT4 inhibitors derived from the lead substance (S)‐SNAP‐5114 have been synthesized and characterized for their inhibitory potency. Variations from the parent compound included the substitution of one of its aromatic 4‐methoxy and 4‐methoxyphenyl groups,… read more here.
Keywords: one aromatic; substituted nipecotic; aromatic methoxy; methoxy ... See more keywords
Molecular basis of human GABA transporter 3 inhibition
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DOI: 10.1038/s41467-025-59066-w
Abstract: γ-Aminobutyric acid (GABA) transporters (GATs) are sodium- and chloride-dependent transporters that mediate the reuptake of the inhibitory neurotransmitter GABA after its release from synaptic vesicles. GAT3 transports GABA from the synaptic cleft into astrocytes and… read more here.
Keywords: inhibition; gaba transporter; gat3; snap 5114 ... See more keywords