Snap-Trapping Strategy for Amine-Specific Bioconjugation with Pyridotriazole Carbaldehydes.
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DOI: 10.1021/jacs.5c15886
Abstract: While thiol-targeting methods have long defined the gold standard in bioconjugation, selective and clean modification of more abundant but intrinsically less nucleophilic amine groups remains a challenge. Methods that match the reactivity and precision of… read more here.
Keywords: amine; snap trapping; amine specific; trapping strategy ... See more keywords