Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13018
Abstract: As a SNARE binding protein, tomosyn has been reported to negatively regulate synaptic exocytosis via arresting syntaxin‐1 and SNAP‐25 into a nonfusogenic product that precludes synaptobrevin‐2 entry, raising the question how the assembly of the… read more here.
Keywords: snare; snare complex; syntaxin; munc18 ... See more keywords
Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13394
Abstract: Neurotransmitter release by Ca2+‐triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N‐ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin‐1, SNAP‐25, and synaptobrevin‐2 form the SNARE complex to bring… read more here.
Keywords: complex assembly; neuronal snare; snare complex; munc18 munc13 ... See more keywords
Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13503
Abstract: Characterizing interactions of Synaptotagmin‐1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X‐ray crystallography revealed how the Synaptotagmin‐1 C2B domain binds to the SNARE complex through a so‐called primary interface… read more here.
Keywords: snare; tripartite interface; complexin; synaptotagmin snare ... See more keywords
MTOR-mediates hepatic lipid metabolism through an autophagic SNARE complex
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2037853
Abstract: ABSTRACT The STX17-SNAP29-VAMP8 SNARE complex mediates autophagosome-lysosome fusion. Our recent study showed that MTOR directly phosphorylates VAMP8ʹs T48 residue in nutrient-rich conditions. Phosphorylated VAMP8 inhibits autophagosome-lysosome fusion by blocking STX17-SNAP29-VAMP8 SNARE complex formation. Our study… read more here.
Keywords: lysosome fusion; snare; autophagosome lysosome; lipid metabolism ... See more keywords
Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2064624
Abstract: ABSTRACT SCFD1 (sec1 family domain containing 1) was recently shown to function in autophagosome-lysosome fusion, and multiple studies have demonstrated the regulatory impacts of acetylation (a post-translational modification) on macroautophagy/autophagy. Here, we demonstrate that both… read more here.
Keywords: lysosome fusion; acetylation; scfd1; autophagosome lysosome ... See more keywords
Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-01-0019
Abstract: Intracellular membrane fusion requires Rab-family GTPases, their effector tethers, soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, and SNARE chaperones of the Sec1/Munc18 (SM), Sec17/α-SNAP, and Sec18/NSF families. We have developed an assay using fluorescence… read more here.
Keywords: catalyze snare; snare; complex assembly; membrane ... See more keywords
SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.03.05.483126
Abstract: Munc18-1 forms a template to recruit and organize assembly of the SNARE complex that triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where its N-terminal region interacts with the SNARE motif, and… read more here.
Keywords: snare; cryo structures; syntaxin; complex assembly ... See more keywords
The MCTP-SNARE Complex Regulates Florigen Transport in Arabidopsis
Sign Up to like & getrecommendations! Published in 2019 at "Plant Cell"
DOI: 10.1105/tpc.18.00960
Abstract: Endosomal trafficking mediated by the MCTP-SNARE complex is essential for the export of florigen from phloem companion cells to sieve elements to induce flowering in Arabidopsis. Multiple flowering pathways in Arabidopsis (Arabidopsis thaliana) converge on… read more here.
Keywords: transport; snare complex; companion cells; mctp snare ... See more keywords
Tyramine synthesis, vesicular packaging, and the SNARE complex function coordinately in astrocytes to regulate Drosophila alcohol sedation
Sign Up to like & getrecommendations! Published in 2021 at "Addiction Biology"
DOI: 10.1111/adb.13019
Abstract: Identifying mechanisms underlying alcohol‐related behaviors could provide important insights regarding the etiology of alcohol use disorder. To date, most genetic studies on alcohol‐related behavior in model organisms have focused on neurons, leaving the causal roles… read more here.
Keywords: snare complex; tyramine; alcohol sedation; sedation ... See more keywords
Lateral Fluid Percussion Injury Impairs Hippocampal Synaptic Soluble N-Ethylmaleimide Sensitive Factor Attachment Protein Receptor Complex Formation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2017.00532
Abstract: Traumatic brain injury (TBI) and the activation of secondary injury mechanisms have been linked to impaired cognitive function, which, as observed in TBI patients and animal models, can persist for months and years following the… read more here.
Keywords: complex formation; formation; snare complex; injury ... See more keywords
A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00256
Abstract: The Ca2+ sensor synaptotagmin-1 (Syt1) plays an essential function in synaptic exocytosis. Recently, Syt1 has been implicated in synaptic vesicle priming, a maturation step prior to Ca2+-triggered membrane fusion that is believed to involve formation… read more here.
Keywords: snare; stimulation; munc18 munc13; snare complex ... See more keywords