Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121259119
Abstract: Significance The speed of neural information processing in the human central nervous system is ultimately determined by the speed of chemical transmission at synapses, because action potentials have relatively short distances to traverse. The release… read more here.
Keywords: release; six copies; exactly six; state ... See more keywords
ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis
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DOI: 10.7554/elife.25327
Abstract: Intracellular membrane fusion mediates diverse processes including cell growth, division and communication. Fusion involves complex formation between SNARE proteins anchored to adjacent membranes. How and in what form interacting SNARE proteins reach their sites of… read more here.
Keywords: snare; cytokinesis; snare proteins; formation ... See more keywords
Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.26646
Abstract: At physiological protein levels, the slow HOPS- and SNARE-dependent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without requiring ATP hydrolysis. To stimulate, Sec17 needs its central residues which bind… read more here.
Keywords: sec17 sec18; snare; sec18 act; fusion ... See more keywords
NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
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DOI: 10.7554/elife.36497
Abstract: SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individual SNARE… read more here.
Keywords: snare; nsf mediated; snare complex; complexin ... See more keywords