SNARE proteins play a role in motor axon guidance in vertebrates and invertebrates
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22481
Abstract: Axonal growth and guidance rely on correct growth cone responses to guidance cues, both in the central nervous system (CNS) and in the periphery. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics,… read more here.
Keywords: axon guidance; snare proteins; guidance; motor axon ... See more keywords
Aberrant autophagy in lysosomal storage disorders marked by a lysosomal SNARE protein shortage due to suppression of endocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12558
Abstract: Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by genetic defects in lysosomal enzymes or related factors. LSDs are associated with excessive accumulation of natural substrates in lysosomes leading to central nervous system and… read more here.
Keywords: snare; storage disorders; lysosomal storage; endocytosis ... See more keywords
Identifying SNARE Proteins Using an Alignment-Free Method Based on Multiscan Convolutional Neural Network and PSSM Profiles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01034
Abstract: Background: SNARE proteins play a vital role in membrane fusion and cellular physiology and pathological processes. Many potential therapeutics for mental diseases or even cancer based on SNAREs are also developed. Therefore, there is a… read more here.
Keywords: neural network; snare; pssm profiles; convolutional neural ... See more keywords
SNARE proteins: zip codes in vesicle targeting?
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210719
Abstract: Membrane traffic in eukaryotic cells is mediated by transport vesicles that bud from a precursor compartment and are transported to their destination compartment where they dock and fuse. To reach their intracellular destination, transport vesicles… read more here.
Keywords: targeting signals; codes vesicle; snare proteins; zip codes ... See more keywords
SNARE protein VAMP-2, but not syntaxin-1, SNAP-25 and synaptotagmin 1, expressed in perisynaptic astrocytic processes in the CA1 area of the rat hippocampus
Sign Up to like & getrecommendations! Published in 2022 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001861
Abstract: Objective Perisynaptic astrocytic processes have been suggested as sites for the regulated release of neuroactive substances. However, very little is known about the molecular properties of regulated exocytosis in these processes. Soluble N-ethylmaleimide-sensitive-factor attachment protein… read more here.
Keywords: perisynaptic astrocytic; vamp; astrocytic processes; snare proteins ... See more keywords
The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.02092-20
Abstract: The phylum of Apicomplexa groups medically relevant parasites such as those responsible for malaria and toxoplasmosis. As members of the Alveolata superphylum, these protozoans possess specialized organelles in addition to those found in all members… read more here.
Keywords: vesicular trafficking; snare proteins; zip code; munc18 snare ... See more keywords
ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260546
Abstract: ABSTRACT Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly formed double-membrane structure called the autophagosome, and subsequently targeted for degradation in the lytic compartment of the cell. The fusion… read more here.
Keywords: ykt6; snare; ulk1 mediated; role ... See more keywords
Cardiac SNARE Expression in Health and Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00881
Abstract: SNARE proteins are integral to intracellular vesicular trafficking, which in turn is the process underlying the regulated expression of substrate transporters such as the glucose transporter GLUT4 at the cell surface of insulin target tissues.… read more here.
Keywords: snare; cardiac tissue; snare proteins; disease ... See more keywords
Drunken lipid membranes, not drunken SNARE proteins, promote fusion in a model of neurotransmitter release
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1022756
Abstract: Alcohol affects many neuronal proteins that are upstream or down-stream of synaptic vesicle fusion and neurotransmitter release. Less well studied is alcohol’s effect on the fusion machinery including SNARE proteins and lipid membranes. Using a… read more here.
Keywords: lipid membranes; fusion; neurotransmitter release; snare proteins ... See more keywords
High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans
Sign Up to like & getrecommendations! Published in 2017 at "Toxins"
DOI: 10.3390/toxins9120404
Abstract: The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins:… read more here.
Keywords: snare; snare proteins; botulinum neurotoxins; cleavage sites ... See more keywords
ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.25327
Abstract: Intracellular membrane fusion mediates diverse processes including cell growth, division and communication. Fusion involves complex formation between SNARE proteins anchored to adjacent membranes. How and in what form interacting SNARE proteins reach their sites of… read more here.
Keywords: snare; cytokinesis; snare proteins; formation ... See more keywords