SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson’s disease in Chinese population
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DOI: 10.1007/s00415-019-09336-7
Abstract: BackgroundRecently, rs2421947 in DNM3 (dynamin 3) was reported as a genetic modifier of age at onset (AAO) of LRRK2 G2019S-related Parkinson’s disease (PD) in a genome-wide association study in Arab-Berber population. Rs356219 in SNCA (α-synuclein)… read more here.
Keywords: snca; dnm3; chinese population; lrrk2 related ... See more keywords
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models
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DOI: 10.1080/15548627.2021.2016256
Abstract: ABSTRACT Accumulation of the neuronal protein SNCA/alpha-synuclein and of the oligodendroglial phosphoprotein TPPP/p25A within the glial cytoplasmic inclusions (GCIs) represents the key histophathological hallmark of multiple system atrophy (MSA). Even though the levels/distribution of both… read more here.
Keywords: system; tppp; snca; tppp p25a ... See more keywords
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
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DOI: 10.1080/15548627.2022.2045534
Abstract: ABSTRACT Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggests the involvement of autophagy as… read more here.
Keywords: microscopy; ctsd cathepsin; ctsd; snca ... See more keywords
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0873-5
Abstract: Synucleinopathies are mostly sporadic neurodegenerative disorders of partly unexplained aetiology, and include Parkinson’s disease (PD) and multiple system atrophy (MSA). We have further investigated our recent finding of somatic SNCA (α-synuclein) copy number variants (CNVs,… read more here.
Keywords: snca; msa; single cell; somatic cnvs ... See more keywords
Regulation of Parkinson’s disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0275235
Abstract: Parkinson’s disease is the second most common age-related, neurodegenerative disease. A small collection of genes has been linked to Parkinson’s disease including LRRK2, SAT1, and SNCA, the latter of which encodes the protein alpha-synuclein that… read more here.
Keywords: disease; pumilio proteins; parkinson disease; snca ... See more keywords