SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson’s disease in Chinese population
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DOI: 10.1007/s00415-019-09336-7
Abstract: BackgroundRecently, rs2421947 in DNM3 (dynamin 3) was reported as a genetic modifier of age at onset (AAO) of LRRK2 G2019S-related Parkinson’s disease (PD) in a genome-wide association study in Arab-Berber population. Rs356219 in SNCA (α-synuclein)… read more here.
Keywords: snca; dnm3; chinese population; lrrk2 related ... See more keywords
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models
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DOI: 10.1080/15548627.2021.2016256
Abstract: ABSTRACT Accumulation of the neuronal protein SNCA/alpha-synuclein and of the oligodendroglial phosphoprotein TPPP/p25A within the glial cytoplasmic inclusions (GCIs) represents the key histophathological hallmark of multiple system atrophy (MSA). Even though the levels/distribution of both… read more here.
Keywords: system; tppp; snca; tppp p25a ... See more keywords
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2045534
Abstract: ABSTRACT Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggests the involvement of autophagy as… read more here.
Keywords: microscopy; ctsd cathepsin; ctsd; snca ... See more keywords
PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology
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DOI: 10.1080/15548627.2024.2448914
Abstract: ABSTRACT The aggregation and transmission of SNCA/α-synuclein (synuclein, alpha) is a hallmark pathology of Parkinson disease (PD). PLK2 (polo like kinase 2) is an evolutionarily conserved serine/threonine kinase that is more abundant in the brains… read more here.
Keywords: snca synuclein; pathology; plk2; kinase ... See more keywords
R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation
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DOI: 10.1080/15548627.2025.2483886
Abstract: ABSTRACT The presence of neuronal Lewy bodies mainly composed of SNCA/α-synuclein aggregations is a pathological feature of Parkinson disease (PD), whereas reducing SNCA protein levels may slow the progression of this disease. We hypothesized that… read more here.
Keywords: disease; snca synuclein; autophagic degradation; r406 structural ... See more keywords
Internalized SNCA/α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade SNCA fibrils.
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DOI: 10.1080/15548627.2025.2579147
Abstract: ABSTRACT Parkinson disease (PD) and other α-synucleinopathies are characterized by the intracellular aggregates of SNCA/α-synuclein (synuclein, alpha) thought to spread via cell-to-cell transmission. To understand the contributions of various brain cells to the spreading of… read more here.
Keywords: snca aggregates; snca fibrils; snca synuclein; internalized snca ... See more keywords
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing
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DOI: 10.1186/s40478-019-0873-5
Abstract: Synucleinopathies are mostly sporadic neurodegenerative disorders of partly unexplained aetiology, and include Parkinson’s disease (PD) and multiple system atrophy (MSA). We have further investigated our recent finding of somatic SNCA (α-synuclein) copy number variants (CNVs,… read more here.
Keywords: snca; msa; single cell; somatic cnvs ... See more keywords
Regulation of Parkinson’s disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells
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DOI: 10.1371/journal.pone.0275235
Abstract: Parkinson’s disease is the second most common age-related, neurodegenerative disease. A small collection of genes has been linked to Parkinson’s disease including LRRK2, SAT1, and SNCA, the latter of which encodes the protein alpha-synuclein that… read more here.
Keywords: disease; pumilio proteins; parkinson disease; snca ... See more keywords