FET fusion oncoproteins interact with BRD4 and SWI/SNF chromatin remodelling complex subtypes in sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13195
Abstract: FET fusion oncoproteins containing one of the FET (FUS, EWSR1, TAF15) family proteins juxtaposed to alternative transcription‐factor partners are characteristic of more than 20 types of sarcoma and leukaemia. FET oncoproteins bind to the SWI/SNF… read more here.
Keywords: fet oncoproteins; swi snf; fet fusion; chromatin ... See more keywords
Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.017
Abstract: The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 subunit of SWI/SNF is a tumor suppressor frequently lost in pediatric rhabdoid cancers.… read more here.
Keywords: aberrant swi; snf5; swi snf; snf ... See more keywords
Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers.
Sign Up to like & getrecommendations! Published in 2017 at "Joint Commission journal on quality and patient safety"
DOI: 10.1016/j.jcjq.2017.06.004
Abstract: BACKGROUND One in four Medicare patients hospitalized for acute medical illness is discharged to a skilled nursing facility (SNF); 23% of these patients are readmitted to the hospital within 30 days. The care transition from… read more here.
Keywords: snf providers; hospital snf; snf; care transitions ... See more keywords
Water-stable natural silk nanofibril composite films for electrical devices
Sign Up to like & getrecommendations! Published in 2020 at "Materials today communications"
DOI: 10.1016/j.mtcomm.2019.100776
Abstract: Abstract Natural silk nanofibrils (SNF) have received extensive interest for functional devices. However, SNF materials are not stable in water, limiting their use in aqueous or humid environments. We explored the possibility of improving mechanical… read more here.
Keywords: water; natural silk; silk; rsf ... See more keywords
High burn-up spent nuclear fuel transport reliability investigation
Sign Up to like & getrecommendations! Published in 2018 at "Nuclear Engineering and Design"
DOI: 10.1016/j.nucengdes.2018.02.007
Abstract: Abstract Transportation packages for spent nuclear fuel (SNF) must meet safety requirements under normal and accident conditions as specified by federal regulations. During road or rail transportation, SNF will experience unique conditions that could affect… read more here.
Keywords: transportation; nuclear fuel; spent nuclear; reliability ... See more keywords
A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3853
Abstract: Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood.… read more here.
Keywords: smarcd2 containing; mswi snf; snf complex; granulopoiesis ... See more keywords
Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01935-9
Abstract: A recent study published in Nature by Radko-Juettner and colleagues reports an unexpected mutant-speci fi c synthetic lethality in which the E3 protein ubiquitin ligase DCAF5 speci fi cally degrades mutant but not wild-type SWI/SNF… read more here.
Keywords: snf; elimination mutant; function; snf complexes ... See more keywords
Structure of the yeast Swi/Snf complex in a nucleosome free state
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17229-x
Abstract: SWI/SNF remodelers play a key role in regulating chromatin architecture and gene expression. Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf complex in a nucleosome-free state. The structure consists of a stable… read more here.
Keywords: yeast swi; structure; snf complex; swi snf ... See more keywords
The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development
Sign Up to like & getrecommendations! Published in 2024 at "Biochemical Society Transactions"
DOI: 10.1042/bst20230416
Abstract: ATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type switching or for… read more here.
Keywords: development; snf; cell; swi snf ... See more keywords
Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221175120
Abstract: Significance H3K27M mutant DMGs including DIPGs are deadly childhood brain cancers. More than 250 clinical trials over the past 50 y have failed to yield effective therapies. This underscores the importance of understanding the biology… read more here.
Keywords: snf atpases; swi snf; targeting swi; atpases 3k27m ... See more keywords
Monte Carlo Simulations of Spent Nuclear Fuel Dry Storage Cask Measurements with a New External Remote Monitoring System for Developing Safeguards Approaches
Sign Up to like & getrecommendations! Published in 2024 at "Nuclear Technology"
DOI: 10.1080/00295450.2024.2397195
Abstract: Abstract Until a long-term solution for the disposal of spent nuclear fuel (SNF) is available, interim dry casks will be increasingly used for the storage of SNF discharged from civilian nuclear power reactors. Dry casks… read more here.
Keywords: fuel; snf; spent nuclear; monitoring ... See more keywords