Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
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DOI: 10.1038/s41388-021-01781-x
Abstract: Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encoding genes in 20–25% of all human cancers, frequently driving oncogenic… read more here.
Keywords: chromatin remodelling; chromatin; snf chromatin; remodelling complexes ... See more keywords