SMARCA4 and SMARCE1 in gastric cancer: Correlation with ARID1A, and microsatellite stability, and SMARCE1 / ERBB2 co‐amplification
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5776
Abstract: Recent studies have shown an association between certain subunits of the SWI/SNF complex with specific tumor characteristics in gastric cancer (GC). In an earlier study, we applied multiregional whole exome sequencing on multiple primary tumor… read more here.
Keywords: cancer; swi snf; gastric cancer; smarca4 smarce1 ... See more keywords
A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3853
Abstract: Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood.… read more here.
Keywords: smarcd2 containing; mswi snf; snf complex; granulopoiesis ... See more keywords
Structure of the yeast Swi/Snf complex in a nucleosome free state
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17229-x
Abstract: SWI/SNF remodelers play a key role in regulating chromatin architecture and gene expression. Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf complex in a nucleosome-free state. The structure consists of a stable… read more here.
Keywords: yeast swi; structure; snf complex; swi snf ... See more keywords
Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221175120
Abstract: Significance H3K27M mutant DMGs including DIPGs are deadly childhood brain cancers. More than 250 clinical trials over the past 50 y have failed to yield effective therapies. This underscores the importance of understanding the biology… read more here.
Keywords: snf atpases; swi snf; targeting swi; atpases 3k27m ... See more keywords
The TRIPLE PHD FINGERS proteins are required for SWI/SNF complex-mediated +1 nucleosome positioning and transcription start site determination in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac826
Abstract: Abstract Eukaryotes have evolved multiple ATP-dependent chromatin remodelers to shape the nucleosome landscape. We recently uncovered an evolutionarily conserved SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeler complex in plants reminiscent of the mammalian BAF subclass, which specifically… read more here.
Keywords: positioning transcription; swi snf; transcription; nucleosome positioning ... See more keywords
MBRS-63. THE ROLE OF THE SWI/SNF COMPLEX SUBUNIT SMARCD3 IN MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.567
Abstract: Abstract Medulloblastoma is the most common malignant brain tumor in children, with the Group 3 (G3) having the worst prognosis of the subgroups (WNT, SHH, and Group 4). We aimed to determine the underlying differences… read more here.
Keywords: smarcd3; medulloblastoma; role; snf complex ... See more keywords
Advances in the role of SWI/SNF complexes in tumours
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17709
Abstract: Cancer development is a complex process involving both genetic and epigenetic changes. The SWI/SNF (switch/sucrose non‐fermentable) chromatin remodelling complex, one of the most studied ATP‐dependent complexes, plays an important role in coordinating chromatin structural stability,… read more here.
Keywords: encoding subunits; swi snf; genes encoding; role ... See more keywords
Loss of SWI/SNF complex expression in undifferentiated renal carcinoma in acquired cystic kidney
Sign Up to like & getrecommendations! Published in 2018 at "Pathology International"
DOI: 10.1111/pin.12671
Abstract: To the Editor: Loss of the SWI/SNF complex has recently been reported in carcinomas of various organs, including stomach, kidneys, upper urinary tract, and the lung. These carcinomas exhibited similar morphology, undifferentiated pleomorphic or rhabdoid… read more here.
Keywords: carcinoma; renal carcinoma; snf complex; swi snf ... See more keywords
The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-0963
Abstract: Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How… read more here.
Keywords: drosophila imaginal; smarcb1 hsnf5; snr1; snf complex ... See more keywords
Abstract LB-096: SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-lb-096
Abstract: The gene encoding SMARCB1 (SNF5/INI1/BAF47), a core subunit of the SWI/SNF (BAF) chromatin remodeling complex, is biallelically inactivated in nearly all rhabdoid tumors (RTs), highly aggressive and lethal cancers of early childhood. RTs are among… read more here.
Keywords: mediated swi; smarcb1 mediated; snf complex; swi snf ... See more keywords
SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0813
Abstract: By analyzing all 31 SWI/SNF complex genes, the authors show SWI/SNF complex alterations are associated with improved clinical outcomes following immune checkpoint inhibitor (ICI) therapy across cancer types, suggesting that such alterations could serve as… read more here.
Keywords: biomarker; snf complex; swi snf; immune checkpoint ... See more keywords