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Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5776
Abstract: Recent studies have shown an association between certain subunits of the SWI/SNF complex with specific tumor characteristics in gastric cancer (GC). In an earlier study, we applied multiregional whole exome sequencing on multiple primary tumor…
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Keywords:
cancer;
swi snf;
gastric cancer;
smarca4 smarce1 ... See more keywords
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1
Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3853
Abstract: Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood.…
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Keywords:
smarcd2 containing;
mswi snf;
snf complex;
granulopoiesis ... See more keywords
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Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17229-x
Abstract: SWI/SNF remodelers play a key role in regulating chromatin architecture and gene expression. Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf complex in a nucleosome-free state. The structure consists of a stable…
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Keywords:
yeast swi;
structure;
snf complex;
swi snf ... See more keywords
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Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221175120
Abstract: Significance H3K27M mutant DMGs including DIPGs are deadly childhood brain cancers. More than 250 clinical trials over the past 50 y have failed to yield effective therapies. This underscores the importance of understanding the biology…
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Keywords:
snf atpases;
swi snf;
targeting swi;
atpases 3k27m ... See more keywords
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Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac826
Abstract: Abstract Eukaryotes have evolved multiple ATP-dependent chromatin remodelers to shape the nucleosome landscape. We recently uncovered an evolutionarily conserved SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeler complex in plants reminiscent of the mammalian BAF subclass, which specifically…
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Keywords:
positioning transcription;
swi snf;
transcription;
nucleosome positioning ... See more keywords
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Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.567
Abstract: Abstract Medulloblastoma is the most common malignant brain tumor in children, with the Group 3 (G3) having the worst prognosis of the subgroups (WNT, SHH, and Group 4). We aimed to determine the underlying differences…
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Keywords:
smarcd3;
medulloblastoma;
role;
snf complex ... See more keywords
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Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17709
Abstract: Cancer development is a complex process involving both genetic and epigenetic changes. The SWI/SNF (switch/sucrose non‐fermentable) chromatin remodelling complex, one of the most studied ATP‐dependent complexes, plays an important role in coordinating chromatin structural stability,…
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Keywords:
encoding subunits;
swi snf;
genes encoding;
role ... See more keywords
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Published in 2018 at "Pathology International"
DOI: 10.1111/pin.12671
Abstract: To the Editor: Loss of the SWI/SNF complex has recently been reported in carcinomas of various organs, including stomach, kidneys, upper urinary tract, and the lung. These carcinomas exhibited similar morphology, undifferentiated pleomorphic or rhabdoid…
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Keywords:
carcinoma;
renal carcinoma;
snf complex;
swi snf ... See more keywords
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Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-0963
Abstract: Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How…
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Keywords:
drosophila imaginal;
smarcb1 hsnf5;
snr1;
snf complex ... See more keywords
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Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-lb-096
Abstract: The gene encoding SMARCB1 (SNF5/INI1/BAF47), a core subunit of the SWI/SNF (BAF) chromatin remodeling complex, is biallelically inactivated in nearly all rhabdoid tumors (RTs), highly aggressive and lethal cancers of early childhood. RTs are among…
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Keywords:
mediated swi;
smarcb1 mediated;
snf complex;
swi snf ... See more keywords
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Published in 2023 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0813
Abstract: By analyzing all 31 SWI/SNF complex genes, the authors show SWI/SNF complex alterations are associated with improved clinical outcomes following immune checkpoint inhibitor (ICI) therapy across cancer types, suggesting that such alterations could serve as…
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Keywords:
biomarker;
snf complex;
swi snf;
immune checkpoint ... See more keywords