Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours
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DOI: 10.1038/s41392-024-01935-9
Abstract: A recent study published in Nature by Radko-Juettner and colleagues reports an unexpected mutant-speci fi c synthetic lethality in which the E3 protein ubiquitin ligase DCAF5 speci fi cally degrades mutant but not wild-type SWI/SNF… read more here.
Keywords: snf; elimination mutant; function; snf complexes ... See more keywords