Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10554-1
Abstract: Serum neurofilament light chain (sNfL) is an established biomarker of neuro-axonal damage in multiple neurological disorders. Raised sNfL levels have been reported in adults infected with pandemic coronavirus disease 2019 (COVID-19). Levels in children infected… read more here.
Keywords: antibody; moderate covid; covid; asymptomatic moderate ... See more keywords
Serum neurofilament light is a sensitive biomarker that reflects grey matter volume in Japanese patients with multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2021.117528
Abstract: OBJECTIVE To evaluate the degree of neuroaxonal injury in Japanese multiple sclerosis (MS) patients using serum neurofilament light (sNfL) and to investigate the relationship of sNFL with the degree of brain volume. METHODS sNfL levels… read more here.
Keywords: volume; grey matter; matter volume; japanese patients ... See more keywords
Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers"
DOI: 10.1080/1354750x.2023.2172211
Abstract: Abstract Background: Functionally relevant coronary artery disease (fCAD), causing symptoms of myocardial ischemia, can currently only be reliably detected with advanced cardiac imaging. Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury known… read more here.
Keywords: relevant coronary; snfl; functionally relevant; death ... See more keywords
Letter by Li et al Regarding Article, "NfL (Neurofilament Light Chain) Levels as a Predictive Marker for Long-Term Outcome After Ischemic Stroke".
Sign Up to like & getrecommendations! Published in 2019 at "Stroke"
DOI: 10.1161/strokeaha.119.027955
Abstract: To the Editor: We have read the article written by Uphaus et al with great interest and appreciation. This study revealed sNFL (serum neuron–specific neurofilament light chain) is a good biomarker for functional independence 90… read more here.
Keywords: light chain; outcome; long term; snfl ... See more keywords
Response by Uphaus et al to Letter Regarding Article, "NfL (Neurofilament Light Chain) Levels as a Predictive Marker for Long-Term Outcome After ischemic Stroke".
Sign Up to like & getrecommendations! Published in 2019 at "Stroke"
DOI: 10.1161/strokeaha.119.028194
Abstract: In Response: We read with great interest a meticulous letter written by Li et al in response to our recent article entitled, “NfL (Neurofilament Light Chain) Levels as a Predictive Marker for Long-Term Outcome After… read more here.
Keywords: term outcome; term; outcome; marker ... See more keywords
Measurement of neurofilaments improves stratification of future disease activity in early multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis"
DOI: 10.1177/13524585211047977
Abstract: BACKGROUND The added value of neurofilament light chain levels in serum (sNfL) to the concept of no evidence of disease activity-3 (NEDA-3) has not yet been investigated in detail. OBJECTIVE To assess whether combination of… read more here.
Keywords: future disease; disease activity; following year; activity ... See more keywords
Increased serum neurofilament light chain concentration indicates poor outcome in Guillain-Barré syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01737-0
Abstract: Background Guillain-Barré syndrome (GBS) is an autoimmune disease that results in demyelination and axonal damage. Five percent of patients die and 20% remain significantly disabled on recovery. Recovery is slow in most cases and eventual… read more here.
Keywords: outcome; admission; guillain barr; concentration ... See more keywords
Levels of Neurofilament Light at the Preataxic and Ataxic Stages of Spinocerebellar Ataxia Type 1
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200257
Abstract: Background and Objectives Neurofilament light (NfL) appears to be a promising fluid biomarker in repeat-expansion spinocerebellar ataxias (SCAs), with piloting studies in mixed SCA cohorts suggesting that NfL might be increased at the ataxic stage… read more here.
Keywords: preataxic ataxic; preataxic individuals; snfl; ataxic stage ... See more keywords
Association of Serum Neurofilament Light Chain With Inner Retinal Layer Thinning in Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200778
Abstract: Background and Objectives Serum neurofilament light chain (sNfL) and optical coherence tomography (OCT)–derived retinal measures (including peripapillary retinal nerve fiber layer [pRNFL] and macular ganglion cell layer/inner plexiform layer [GCIPL] thickness) have been proposed as… read more here.
Keywords: neurofilament light; snfl; layer; age ... See more keywords
Phenotypic correlates of serum neurofilament light chain levels in amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1132808
Abstract: Objective To investigate the relationship between serum levels of the neuroaxonal degeneration biomarker neurofilament light chain (NFL) and phenotype in ALS. Materials and methods Serum NFL (sNFL) concentration was quantified in 209 ALS patients and… read more here.
Keywords: als patients; neurofilament light; snfl; lateral sclerosis ... See more keywords
Serum Neurofilament Light Chain as Biomarker for Cladribine-Treated Multiple Sclerosis Patients in a Real-World Setting
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044067
Abstract: Serum neurofilament light chain (sNfL) is an intensely investigated biomarker in multiple sclerosis (MS). The aim of this study was to explore the impact of cladribine (CLAD) on sNfL and the potential of sNfL as… read more here.
Keywords: neurofilament light; snfl; light chain; real world ... See more keywords