SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio
Sign Up to like & getrecommendations! Published in 2017 at "Journal of human genetics"
DOI: 10.1038/jhg.2017.76
Abstract: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are important biomarkers for disease development and progression. To gain insight into the genetic causes of variance in NLR and PLR in the general population, we conducted genome-wide… read more here.
Keywords: snp heritability; platelet; lymphocyte ratio;
A review of SNP heritability estimation methods
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac067
Abstract: Over the past decade, statistical methods have been developed to estimate single nucleotide polymorphism (SNP) heritability, which measures the proportion of phenotypic variance explained by all measured SNPs in the data. Estimates of SNP heritability… read more here.
Keywords: heritability; heritability estimation; review snp; snp heritability ... See more keywords
A scalable estimator of SNP heritability for biobank-scale data
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty253
Abstract: Motivation Heritability, the proportion of variation in a trait that can be explained by genetic variation, is an important parameter in efforts to understand the genetic architecture of complex phenotypes as well as in the… read more here.
Keywords: symbol; estimator snp; snp heritability; estimator ... See more keywords
Estimating SNP heritability in presence of population substructure in biobank-scale datasets.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac015
Abstract: SNP heritability of a trait is measured as the proportion of total variance explained by the additive effects of genome-wide single nucleotide polymorphisms (SNPs). Linear mixed models are routinely used to estimate SNP heritability for… read more here.
Keywords: presence; heritability; population substructure; snp heritability ... See more keywords