Discovering Genetic Factors for psoriasis through exhaustively searching for significant second order SNP-SNP interactions
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33493-w
Abstract: In this paper, we aim at discovering genetic factors of psoriasis through searching for statistically significant SNP-SNP interactions exhaustively from two real psoriasis genome-wide association study datasets (phs000019.v1.p1 and phs000982.v1.p1) downloaded from the database of… read more here.
Keywords: genetic factors; discovering genetic; snp snp; snp ... See more keywords
ELSSI: parallel SNP-SNP interactions detection by ensemble multi-type detectors
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac213
Abstract: With the development of high-throughput genotyping technology, single nucleotide polymorphism (SNP)-SNP interactions (SSIs) detection has become an essential way for understanding disease susceptibility. Various methods have been proposed to detect SSIs. However, given the disease… read more here.
Keywords: snp snp; ssis; snp; multi type ... See more keywords
Detecting Disease-Associated SNP-SNP Interactions Using Progressive Screening Memetic Algorithm
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2020.3019256
Abstract: Hundreds of thousands of single nucleotide polymorphisms (SNPs)are currently available for genome-wide association study (GWAS). Detecting disease-associated SNP-SNP interactions is considered an important way to capture the underlying genetic causes of complex diseases. In the… read more here.
Keywords: snp snp; detecting disease; snp interactions; associated snp ... See more keywords
SNP x SNP Interactions Elucidate TCF7L2’s Physiology Conveying Incretin Action
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DOI: 10.2337/db18-1717-p
Abstract: Introduction: Genetic polymorphisms in TCF7L2 are the strongest common risk variants for type 2 diabetes. We and others had showed that genetic variation in TCF7L2 affects incretin-stimulated insulin secretion. A recent genome-wide association study discovered… read more here.
Keywords: insulin secretion; snp snp; physiology; snp ... See more keywords
Association of Genetic Polymorphisms in MicroRNAs With Type 2 Diabetes Mellitus in a Chinese Population
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.587561
Abstract: Introduction MicroRNAs (miRNA) involved in the insulin signaling pathways deeply affect the pathogenesis of T2DM. The aim of this study was to assess the association between single nucleotide polymorphisms (SNP) of the related miRNAs (let-7f… read more here.
Keywords: rs13293512 mir; let rs13293512; snp snp; 133a rs13040413 ... See more keywords