CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila
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DOI: 10.1038/s41421-020-0178-7
Abstract: Dear Editor, While the eukaryotic candidate mA methyltransferases belong to multiple distinct methylase lineages, the most widespread group belongs to the MT-A70 family exemplified by the yeast messenger RNA (mRNA) adenine methylase complex Ime4/Kar4. At… read more here.
Keywords: drosophila; methylation; snrna; rna ... See more keywords
m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site
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DOI: 10.1101/2022.04.05.487178
Abstract: Alternative splicing of messenger RNAs is associated with the evolution of developmentally complex eukaryotes. Splicing is mediated by the spliceosome, and docking of the pre-mRNA 5’ splice site into the spliceosome active site depends upon… read more here.
Keywords: m6a modification; site; snrna; splice site ... See more keywords
Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer
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DOI: 10.1136/jmedgenet-2021-108327
Abstract: Most small non-coding RNAs (sncRNAs) with regulatory functions are encoded by majority sequences in the human genome, and the emergence of high-throughput sequencing technology has greatly expanded our understanding of sncRNAs. sncRNAs are composed of… read more here.
Keywords: snorna snrna; snrna; snrna pirna; tsrna snorna ... See more keywords
Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.
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DOI: 10.1261/rna.065458.117
Abstract: Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new… read more here.
Keywords: snrna; prp8; splice site; site ... See more keywords
CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors
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DOI: 10.3390/biom12050704
Abstract: In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated… read more here.
Keywords: snrna; snrna genes; repertoire; cyclin ... See more keywords