CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-0178-7
Abstract: Dear Editor, While the eukaryotic candidate mA methyltransferases belong to multiple distinct methylase lineages, the most widespread group belongs to the MT-A70 family exemplified by the yeast messenger RNA (mRNA) adenine methylase complex Ime4/Kar4. At… read more here.
Keywords: drosophila; methylation; snrna; rna ... See more keywords
Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters
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DOI: 10.1038/s41467-024-55553-8
Abstract: RNA polymerase III (Pol III) is specialized in the transcription of short, essential RNAs, including the U6 small nuclear RNAs (snRNAs). At U6 snRNA genes, Pol III is recruited by the snRNA Activating Protein Complex… read more here.
Keywords: snrna; polymerase; rna polymerase; structural insights ... See more keywords
Cryo-EM structure of human TUT1:U6 snRNA complex
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae1314
Abstract: Abstract U6 snRNA (small nuclear ribonucleic acid) is a ribozyme that catalyzes pre-messenger RNA (pre-mRNA) splicing and undergoes epitranscriptomic modifications. After transcription, the 3′-end of U6 snRNA is oligo-uridylylated by the multi-domain terminal uridylyltransferase (TUTase),… read more here.
Keywords: snrna; structure human; human tut1; snrna complex ... See more keywords
m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site
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DOI: 10.1101/2022.04.05.487178
Abstract: Alternative splicing of messenger RNAs is associated with the evolution of developmentally complex eukaryotes. Splicing is mediated by the spliceosome, and docking of the pre-mRNA 5’ splice site into the spliceosome active site depends upon… read more here.
Keywords: m6a modification; site; snrna; splice site ... See more keywords
Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2021-108327
Abstract: Most small non-coding RNAs (sncRNAs) with regulatory functions are encoded by majority sequences in the human genome, and the emergence of high-throughput sequencing technology has greatly expanded our understanding of sncRNAs. sncRNAs are composed of… read more here.
Keywords: snorna snrna; snrna; snrna pirna; tsrna snorna ... See more keywords
Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.
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DOI: 10.1261/rna.065458.117
Abstract: Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new… read more here.
Keywords: snrna; prp8; splice site; site ... See more keywords
A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3’ processing
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DOI: 10.1371/journal.pgen.1011284
Abstract: The Integrator is a multi-subunit protein complex that catalyzes the maturation of snRNA transcripts via 3’ cleavage, a step required for snRNA incorporation with snRNP for spliceosome biogenesis. Here we developed a GFP based in… read more here.
Keywords: snrna; argonaute protein; csr; processing ... See more keywords
Folic acid and sperm quality improvement: insights from snRNA sequencing and RNA splicing mechanisms
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2025.1648307
Abstract: Folic acid, an essential micronutrient in male reproductive physiology, serves as a critical cofactor in one-carbon metabolism by facilitating nucleotide biosynthesis and epigenetic methylation processes fundamental to spermatogenesis. Its metabolic role is characterized by two… read more here.
Keywords: rna splicing; folate; folic acid; snrna ... See more keywords
CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors
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DOI: 10.3390/biom12050704
Abstract: In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated… read more here.
Keywords: snrna; snrna genes; repertoire; cyclin ... See more keywords