SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes
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DOI: 10.1038/s41598-017-16370-w
Abstract: Sorting nexin 27 (SNX27) recycles PSD-95, Dlg1, ZO-1 (PDZ) domain-interacting membrane proteins and is essential to sustain adequate brain functions. Here we define a fundamental SNX27 function in T lymphocytes controlling antigen-induced transcriptional activation and… read more here.
Keywords: links dgk; snx27 links; dgk control; snx27 ... See more keywords
SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117576119
Abstract: Significance We here established the interaction between PDZ binding motif (PBM) at the C terminal of ACE2 and PDZ domain of sorting nexin 27 (SNX27) and solved the crystal structure of ACE2-PBM/SNX27-PDZ complex. Together with… read more here.
Keywords: cell; snx27; late endosome; ace2 ... See more keywords
Retromer involvement in trafficking of the calcium-activated K channel, KCa3.1
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733913
Abstract: The intermediate-conductance Ca2+-activated K+ channel KCa3.1 ( KCNN4) regulates many physiological processes, including, water and electrolyte transport in polarised epithelia and vascular tone. Crucial for KCa3.1 function is the regulation of the number of channels… read more here.
Keywords: retromer; snx27; activated channel; trafficking kca3 ... See more keywords
Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease
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DOI: 10.3389/fcell.2021.642378
Abstract: Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of cellular sorting processes and can drive severe physiological outcomes. Sorting nexin 27 (SNX27) is a metazoan-specific sorting nexin protein from the PX-FERM domain… read more here.
Keywords: snx27 retromer; toward understanding; disease; snx27 ... See more keywords
Endosomal Sorting Protein SNX27 and Its Emerging Roles in Human Cancers
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DOI: 10.3390/cancers15010070
Abstract: Simple Summary The sorting nexin (SNX) family of proteins mediate the sorting and trafficking of endocytosed transmembrane proteins between the endosomal compartments, lysosome, trans-Golgi network, and plasma membrane. SNXs are characterized by the presence of… read more here.
Keywords: pdz domain; snx27; sorting protein; domain ... See more keywords