High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Prostate cancer and prostatic diseases"
DOI: 10.1038/s41391-021-00431-3
Abstract: BACKGROUND Prostate cancer (PCa) is the most frequent cancer in men. The prognosis of PCa is heterogeneous with many clinically indolent tumors and rare highly aggressive cases. Reliable tissue markers of prognosis are lacking. Active… read more here.
Keywords: soat1; high risk; expression; prostate cancer ... See more keywords
Abstract 5880: The role of SOAT1 on CD8+T cells-mediated immune response in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5880
Abstract: Introduction: Sterol-O acyltransferase 1 (SOAT1) functions by converting cholesterol and acyl-CoA into cholesterol ester and coA-SH. High SOAT1 expression with its mediated tumorigenesis has been shown in multiple cancers. Studies showed that SOAT1 inhibition by… read more here.
Keywords: ovarian cancer; role soat1; mediated immune; soat1 ... See more keywords
piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.
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DOI: 10.18632/aging.203965
Abstract: PURPOSE Previous studies found that piRNAs could participate in disease progression by regulating DNA methylation, but there are few reports on their roles in heart failure (HF). METHODS The level of piRNA-6426 in the venous… read more here.
Keywords: methylation; pirna 6426; heart; pirna ... See more keywords