Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-57732-6_25
Abstract: TRPC channels have been suggested as potential candidates mediating store-operated Ca2+ entry (SOCE) in cardiomyocytes. There is increasing evidence that the TRPC isoforms TRPC1 and TRPC4 might fulfill the function as SOCs, in concert with… read more here.
Keywords: trpc channels; disease; trpc; pathology ... See more keywords
Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.006
Abstract: Esophageal cancer (EC) is the 6th leading cause of cancer mortality worldwide with poor prognosis, hence more effective chemotherapeutic drugs for this deadly disease are urgently needed. We previously reported that high expression of Orai1,… read more here.
Keywords: orai1 mediated; store operated; rp4010; cancer ... See more keywords
SOCE and STIM1 signaling in the heart: Timing and location matter.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.11.008
Abstract: Store operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to… read more here.
Keywords: stim1; stim1 signaling; soce stim1; signaling heart ... See more keywords
Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0039-4
Abstract: Ca2+ plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca2+ across the ER membrane, but the exact effect of Bcl-2… read more here.
Keywords: apoptosis; stress; bcl; soce ... See more keywords
Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aav4663
Abstract: SOCE mediated by ORAI1 affects the metabolism, redox status, and function of enamel cells in teeth. Preventing CRAC’d teeth Store-operated Ca2+ entry (SOCE) through CRAC channels, specifically complexes formed by ORAI Ca2+ channels and STIM… read more here.
Keywords: enamel cells; orai; ca2; soce ... See more keywords
Abstract C045: RP4010, a small molecule inhibitor of Store-Operated Calcium Entry (SOCE), potentiates activity of Gilteritinib and Cytarabine in preclinical models of AML
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c045
Abstract: Background: Store-operated calcium entry (SOCE) through calcium release activated calcium (CRAC) channels contribute to calcium influx in non-excitable cells. Elevation of cytosolic calcium through SOCE mediates an array of cellular responses including metabolism and gene… read more here.
Keywords: soce; operated calcium; calcium entry; activity ... See more keywords
Abstract 3552: Induction of store operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3552
Abstract: Glioblastomas (GBM) are the most aggressive brain cancers without effective therapeutics. The Hippo pathway transcriptional coactivators YAP/TAZ were implicated as drivers in GBM progression and could be therapeutic targets. Here, we found in an unbiased… read more here.
Keywords: transcriptional coactivators; pathway transcriptional; hippo pathway; yap taz ... See more keywords
Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients withmyeloproliferative neoplasms.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019001103
Abstract: About one fourth of patients with essential thrombocythemia or primary myelofibrosis carry a somatic mutation of CALR, the gene encoding for calreticulin. A 52-bp deletion (Type I mutation) and a 5-bp insertion (Type II mutation)… read more here.
Keywords: mutant calreticulin; calreticulin; megakaryocytes patients; myeloproliferative neoplasms ... See more keywords
Lysosomal agents inhibit store-operated Ca2+ entry
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.248658
Abstract: ABSTRACT Pharmacological manipulation of lysosome membrane integrity or ionic movements is a key strategy for probing lysosomal involvement in cellular processes. However, we have found an unexpected inhibition of store-operated Ca2+ entry (SOCE) by these… read more here.
Keywords: store operated; agents inhibit; operated ca2; lysosomal agents ... See more keywords
Efficacy and risk of sexual orientation change efforts: a retrospective analysis of 125 exposed men.
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.51209.1
Abstract: BACKGROUND Voluntary therapeutic interventions to reduce unwanted same-sex sexuality are collectively known as sexual orientation change efforts (SOCE). To date almost all evidence addressing the contested question whether SOCE is effective or safe has consisted of anecdotes or very small sample qualitative studies of… read more here.
Keywords: change; orientation change; orientation; sexual orientation ... See more keywords
Absence of Behavioral Harm Following Non-efficacious Sexual Orientation Change Efforts: A Retrospective Study of United States Sexual Minority Adults, 2016–2018
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2022.823647
Abstract: Background Do sexual minority persons who have undergone unsuccessful sexual orientation change efforts (SOCE) suffer subsequent psychological or social harm from the attempt? Previous studies have conflated present and past, even pre-SOCE, harm in addressing… read more here.
Keywords: behavioral harm; soce; sexual minority; minority ... See more keywords