Maxacalcitol alleviates diabetes-associated periodontitis in male mice by restoring Treg/Th17 balance via SOCE-mediated mitochondrial dysfunction.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of periodontology"
DOI: 10.1002/jper.70002
Abstract: BACKGROUND CD4+ T lymphocytes play a central role in the pathogenesis of periodontitis, with the Treg/Th17 (regulatory T cell/T helper 17 cell) imbalance closely linked to diabetes-associated periodontitis (DPD). Maxacalcitol (OCT), an analog of active… read more here.
Keywords: soce; th17 balance; periodontitis; treg th17 ... See more keywords
Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-57732-6_25
Abstract: TRPC channels have been suggested as potential candidates mediating store-operated Ca2+ entry (SOCE) in cardiomyocytes. There is increasing evidence that the TRPC isoforms TRPC1 and TRPC4 might fulfill the function as SOCs, in concert with… read more here.
Keywords: trpc channels; disease; trpc; pathology ... See more keywords
Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.006
Abstract: Esophageal cancer (EC) is the 6th leading cause of cancer mortality worldwide with poor prognosis, hence more effective chemotherapeutic drugs for this deadly disease are urgently needed. We previously reported that high expression of Orai1,… read more here.
Keywords: orai1 mediated; store operated; rp4010; cancer ... See more keywords
SOCE and STIM1 signaling in the heart: Timing and location matter.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.11.008
Abstract: Store operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to… read more here.
Keywords: stim1; stim1 signaling; soce stim1; signaling heart ... See more keywords
PACS-1 Interacts with TRPC3 and ESyt1 to Mediate Protein Trafficking while Promoting SOCE and Cooperatively Regulating Hormone Secretion
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c04998
Abstract: Corticotropic cells of the anterior pituitary gland release adrenocorticotropic hormone (ACTH) in a regulated manner to promote the production of cortisol and androgens. The process of ACTH secretion is partly mediated by the phosphofurin acidic… read more here.
Keywords: soce; pacs; acth secretion; protein ... See more keywords
Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0039-4
Abstract: Ca2+ plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca2+ across the ER membrane, but the exact effect of Bcl-2… read more here.
Keywords: apoptosis; stress; bcl; soce ... See more keywords
Endothelial CRAC Channels.
Sign Up to like & getrecommendations! Published in 2025 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041777
Abstract: Store-operated Ca2+ entry (SOCE) is the primary Ca2+ entry mechanism in nonexcitable cells such as endothelial cells (ECs). When the endoplasmic reticulum (ER)-resident stromal-interacting molecules 1 and 2 (STIM1/2) sense the depletion of Ca2+ stores,… read more here.
Keywords: endothelial crac; crac; soce; crac channels ... See more keywords
Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aav4663
Abstract: SOCE mediated by ORAI1 affects the metabolism, redox status, and function of enamel cells in teeth. Preventing CRAC’d teeth Store-operated Ca2+ entry (SOCE) through CRAC channels, specifically complexes formed by ORAI Ca2+ channels and STIM… read more here.
Keywords: enamel cells; orai; ca2; soce ... See more keywords
A Role for Septin GTPases in regulating cytoplasmic calcium handling in Drosophila cardiomyocytes
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1326
Abstract: Proper calcium handling in cardiomyocytes is paramount to maintaining cardiomyocyte contractility and heart function. Data from our lab and others have established that store operated calcium entry (SOCE) is an essential component of cardiomyocyte calcium… read more here.
Keywords: soce; role; physiology; septin ... See more keywords
Abstract C045: RP4010, a small molecule inhibitor of Store-Operated Calcium Entry (SOCE), potentiates activity of Gilteritinib and Cytarabine in preclinical models of AML
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c045
Abstract: Background: Store-operated calcium entry (SOCE) through calcium release activated calcium (CRAC) channels contribute to calcium influx in non-excitable cells. Elevation of cytosolic calcium through SOCE mediates an array of cellular responses including metabolism and gene… read more here.
Keywords: soce; operated calcium; calcium entry; activity ... See more keywords
Abstract 3552: Induction of store operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3552
Abstract: Glioblastomas (GBM) are the most aggressive brain cancers without effective therapeutics. The Hippo pathway transcriptional coactivators YAP/TAZ were implicated as drivers in GBM progression and could be therapeutic targets. Here, we found in an unbiased… read more here.
Keywords: transcriptional coactivators; pathway transcriptional; hippo pathway; yap taz ... See more keywords