The Non‐Peptide Vasopressin V1b Receptor Antagonist, SSR149415, Ameliorates Spermatogenesis Function in a Mouse Model of Chronic Social Defeat Stress
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DOI: 10.1002/jcb.26040
Abstract: To determine the effects of SSR149415 on testis and spermatogenesis in male mice subjected to chronic social defeat stress, C57BL/6 male mice were divided into two groups: Control and Stress. Then Stress group was subdivided… read more here.
Keywords: social defeat; defeat stress; stress; chronic social ... See more keywords
Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system
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DOI: 10.1007/s00213-017-4612-y
Abstract: RationaleRepeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents.ObjectiveThe aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine… read more here.
Keywords: social defeat; adult; rewarding effects; trkb receptor ... See more keywords
Pharmacological modulation of the behavioral effects of social defeat in memory and learning in male mice
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DOI: 10.1007/s00213-019-05256-6
Abstract: RationalePrevious studies have demonstrated that repeated social defeat (RSD) stress only induces cognitive deficits when experienced during adulthood. However, RSD increases cocaine-rewarding effects in adult and adolescent mice, inducing different expressions of proBDNF in the… read more here.
Keywords: social defeat; administration; mice; cocaine ... See more keywords
Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model
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DOI: 10.1007/s00406-019-01012-1
Abstract: It is reported that dopamine D 1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of ( R,S )-ketamine. However, its role in the antidepressant actions of ( R )-ketamine,… read more here.
Keywords: social defeat; antidepressant actions; dopamine receptors; defeat stress ... See more keywords
Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
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DOI: 10.1007/s12264-020-00473-y
Abstract: Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is… read more here.
Keywords: social defeat; nrem sleep; effect; acute sds ... See more keywords
The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming
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DOI: 10.1016/j.bbi.2019.01.021
Abstract: Exposure to psychosocial stress is known to precipitate the emergence of stress related psychiatric disorders such as depression and anxiety. While mechanisms by which this occurs remain largely unclear, recent evidence points towards a causative… read more here.
Keywords: social defeat; system; defeat; stress ... See more keywords
Repeated social stress leads to contrasting patterns of structural plasticity in the amygdala and hippocampus
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DOI: 10.1016/j.bbr.2018.03.034
Abstract: ABSTRACT Previous studies have demonstrated that repeated immobilization and restraint stress cause contrasting patterns of dendritic reorganization as well as alterations in spine density in amygdalar and hippocampal neurons. Whether social and ethologically relevant stressors… read more here.
Keywords: social stress; social defeat; stress; contrasting patterns ... See more keywords
Orexin signaling during social defeat stress influences subsequent social interaction behaviour and recognition memory
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DOI: 10.1016/j.bbr.2018.05.032
Abstract: &NA; Orexins are neuropeptides synthesized in the lateral hypothalamus that influence arousal, feeding, reward pathways, and the response to stress. However, the role of orexins in repeated stress is not fully characterized. Here, we examined… read more here.
Keywords: orexin; social defeat; recognition; stress ... See more keywords
Chronic vicarious social defeat stress attenuates new-born neuronal cell survival in mouse hippocampus
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DOI: 10.1016/j.bbr.2021.113536
Abstract: Increasing evidence has shown that adult hippocampal neurogenesis is closely related to the pathophysiological condition of depressive disorders. Recently, chronic social defeat stress paradigms have been regarded as important animal models of depression, accompanied with… read more here.
Keywords: social defeat; cell survival; defeat stress; stress ... See more keywords
Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress
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DOI: 10.1016/j.biopsych.2020.10.010
Abstract: BACKGROUND The study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral domains, with time and practical… read more here.
Keywords: social defeat; analysis; defeat stress; behavioral alterations ... See more keywords
Metabolite signature associated with stress susceptibility in socially defeated mice
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DOI: 10.1016/j.brainres.2018.12.020
Abstract: OBJECTIVE Social defeat represents a naturalistic form of conditioned fear and is often used as an animal model of depression. The present study aimed to identify the neurochemicals in select brain regions of mice exposed… read more here.
Keywords: social defeat; susceptibility; defeat stress; mice ... See more keywords