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   Articles with "socs3" as a keyword



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SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells

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recommendations! Published in 2020 at "European Journal of Immunology"

DOI: 10.1002/eji.201948307

Abstract: SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3‐interaction motif, and then… read more here.

Keywords: cytokine; socs3; foxp3 regulatory; cytokine signaling ... See more keywords
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Maternal Socs3 knockdown attenuates postnatal obesity caused by an early life environment of maternal obesity and intrauterine overnutrition in progeny mice

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recommendations! Published in 2021 at "IUBMB Life"

DOI: 10.1002/iub.2526

Abstract: Pathological states in the early life environment of mammalian offspring, including maternal obesity and intrauterine overnutrition, can induce obesity and metabolic disorder later in life. Leptin resistance caused by upregulation of Socs3 in the hypothalamus… read more here.

Keywords: life environment; socs3; group; early life ... See more keywords
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Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

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recommendations! Published in 2019 at "Cell Biology and Toxicology"

DOI: 10.1007/s10565-019-09499-z

Abstract: The aryl hydrocarbon receptor (AHR) is a ligand-activated receptor that regulates the metabolism of several xenobiotics and participates in ocular inflammation. Although severe inflammation is a major risk of retinal damage, the underlying mechanism is… read more here.

Keywords: socs3; hydrocarbon receptor; ahr; stat3 ... See more keywords
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Muscle‐specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation

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recommendations! Published in 2017 at "Cytokine"

DOI: 10.1016/j.cyto.2017.05.016

Abstract: HighlightsSOCS3 deletion in skeletal muscle does not alter LPS‐induced inflammation.SOCS3 does not mediate the anabolic response to leucine in skeletal muscle.Leucine augments the LPS‐induced expression of IL‐6 and STAT3 phosphorylation. Abstract Excessive inflammation reduces skeletal… read more here.

Keywords: socs3; response; muscle; deletion ... See more keywords
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Prognostic significance of SOCS3 and its biological function in colorectal cancer.

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recommendations! Published in 2017 at "Gene"

DOI: 10.1016/j.gene.2017.06.013

Abstract: Colorectal cancer (CRC) is a common malignant tumor, in which the inflammatory microenvironment plays an important role. STAT3 signaling pathway is regarded as the "bridge" between inflammation and cancer, and involved in the development of… read more here.

Keywords: socs3; colorectal cancer; signaling pathway; expression ... See more keywords
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Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling.

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recommendations! Published in 2019 at "Osteoarthritis and cartilage"

DOI: 10.1016/j.joca.2019.05.018

Abstract: OBJECTIVE To investigate the impact of deleting Suppressor of Cytokine Signaling (SOCS)-3 (SOCS3) in chondrocytes during murine skeletal development. METHOD Mice with a conditional Socs3 allele (Socs3fl/fl) were crossed with a transgenic mouse expressing Cre… read more here.

Keywords: socs3; deleting suppressor; cytokine signaling; mice ... See more keywords
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SOCS3 protects against neonatal necrotizing enterocolitis via suppressing NLRP3 and AIM2 inflammasome activation and p65 nuclear translocation.

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recommendations! Published in 2020 at "Molecular immunology"

DOI: 10.1016/j.molimm.2020.03.019

Abstract: BACKGROUND Necrotizing enterocolitis (NEC) is an acquired disorder of mucosal damage characterized by the diffuse or local necrosis of the intestine. The suppressor of cytokine signaling 3 (SOCS3) has been demonstrated to possess anti-inflammatory action… read more here.

Keywords: aim2 inflammasome; socs3; p65 nuclear; nlrp3 aim2 ... See more keywords
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Mechanisms of reduced leptin-mediated satiety signaling during obesity

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recommendations! Published in 2022 at "International Journal of Obesity"

DOI: 10.1038/s41366-022-01079-2

Abstract: Disrupted leptin signaling in vagal afferent neurons contributes to hyperphagia and obesity. Thus, we tested the hypothesis that intrinsic negative regulators of leptin signaling, suppressor of cytokine signaling 3 (SOCS3) and protein tyrosine phosphatase 1B… read more here.

Keywords: leptin mediated; satiety; obesity; vagal afferent ... See more keywords
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Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-00920-x

Abstract: Long bone strength is determined by its outer shell (cortical bone), which forms by coalescence of thin trabeculae at the metaphysis (corticalization), but the factors that control this process are unknown. Here we show that… read more here.

Keywords: socs3; corticalization; bone corticalization; androgen action ... See more keywords
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Knockdown of miR-92a suppresses the stemness of colorectal cancer cells via mediating SOCS3

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2021.2022267

Abstract: ABSTRACT MiRNAs (microRNAs) participate in colorectal cancer (CRC) progression and act as potential biomarkers for CRC prognosis. In this study, we investigated the mechanisms of microRNA-92a (miR-92a) in CRC. Expressions of miR-92a and SOCS3 (Suppressor… read more here.

Keywords: socs3; stemness colorectal; crc; colorectal cancer ... See more keywords
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Ultrasound targeted microbubble destruction-mediated SOCS3 attenuates biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2031384

Abstract: ABSTRACT SOCS3 is low-expressed in breast cancer and may be a potential target. Ultrasound targeted microbubble destruction (UTMD) improved the efficiency of gene transfection. We explored the effects of UTMD-mediated transfection of SOCS3 on the… read more here.

Keywords: breast cancer; mediated socs3; socs3; biological characteristics ... See more keywords