SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad020
Abstract: Early-stage myeloid-derived suppressor cells (eMDSCs) are a newly defined subset of MDSCs in breast cancer tissues, and was related to poor prognosis of breast cancer patients. Compared with classical MDSCs, eMDSCs display exceptional immunosuppressive ability… read more here.
Keywords: deficiency dependent; wnt mtor; socs3 deficiency; myeloid ... See more keywords
Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Innate Immunity"
DOI: 10.1159/000502645
Abstract: Mononuclear phagocytes, such as macrophages and microglia, are key regulators of organ homeostasis including vascularization processes. Here, we investigated the role of the suppressor of cytokine signaling 3 (SOCS3) in myeloid cells as a regulator… read more here.
Keywords: apoptotic endothelial; myeloid socs3; endothelial cells; socs3 deficiency ... See more keywords