Muscle fiber-type specific terminal Schwann cell pathology leads to sprouting deficits following partial denervation in SOD1G93A mice
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.105052
Abstract: Amyotrophic lateral sclerosis (ALS) is an adult-onset disease characterized by the progressive death of motoneurons and denervation of muscle fibers. To restore motor function, surviving motoneurons in partially denervated muscles typically sprout axons to reinnervate… read more here.
Keywords: muscle; pathology; type; sod1g93a mice ... See more keywords
Pleiotropic activity of systemically delivered angiogenin in the SOD1G93A mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.02.022
Abstract: ABSTRACT Loss‐of‐function mutations in the angiogenin (ANG) gene have been identified in familial and sporadic ALS patients. Previous work from our group identified human ANG (huANG) to protect motoneurons in vitro, and provided proof‐of‐concept that… read more here.
Keywords: sod1g93a; huang; treatment; pleiotropic ... See more keywords
Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0272104
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of corticospinal tract motor neurons. Previous studies showed that adenosine-mediated neuromodulation is disturbed in ALS and that vascular endothelial growth factor (VEGF) has a neuroprotective… read more here.
Keywords: system; caffeine; lateral sclerosis; sod1g93a mice ... See more keywords
Protective effects of intrathecal injection of AAV9-RabGGTB-GFP+ in SOD1G93A mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1092607
Abstract: Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that widely affects motor neurons of the CNS. About 20% of patients with ALS have familial ALS (fALS). One of the classic models of ALS are… read more here.
Keywords: sod1g93a mice; rabggtb; rabggtb gfp; aav9 rabggtb ... See more keywords