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Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression

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Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms20184552

Abstract: Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I… read more here.

Keywords: sod1g93a; spinal cord; glu; sod1g93a mouse ... See more keywords