Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice
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DOI: 10.1111/acel.13225
Abstract: Age‐associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice (Sod1−/− mice) recapitulates sarcopenia phenotypes, including… read more here.
Keywords: muscle; deletion; cuznsod; mice ... See more keywords
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma
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DOI: 10.1111/acel.13676
Abstract: The goal of this study was to test the role cellular senescence plays in the increase in inflammation, chronic liver disease, and hepatocellular carcinoma, which are seen in mice null for Cu/Zn-Superoxide dismutase (Sod1KO). To… read more here.
Keywords: necroptosis; sod1ko mice; senescence; mice ... See more keywords