Paeoniflorin ameliorates lipopolysaccharide‐induced acute liver injury by inhibiting oxidative stress and inflammation via SIRT1/FOXO1a/SOD2 signaling in rats
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7471
Abstract: Acute liver injury (ALI) is a poor prognosis and high mortality complication of sepsis. Paeoniflorin (PF) has remarkable anti‐inflammatory effects in different disease models. Here, we explored the protective effect and underlying molecular mechanisms of… read more here.
Keywords: via sirt1; liver injury; acute liver; sirt1 foxo1a ... See more keywords
Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.015
Abstract: The import of superoxide dismutase-2 (SOD2) into mitochondria is vital for the survival of eukaryotic cells. SOD2 is encoded within the nuclear genome and translocated into mitochondria for activation after translation in the cytosol. The… read more here.
Keywords: hsp70; sod2; import; redox balance ... See more keywords
Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2‐tg heart
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.022
Abstract: Abstract SOD2 is the primary antioxidant enzyme neutralizing •O2− in mitochondria. Cardiac‐specific SOD2 overexpression (SOD2‐tg) induces supernormal function and cardiac hypertrophy in the mouse heart. However, the reductive stress imposed by SOD2 overexpression results in… read more here.
Keywords: heart; acetylation; sod2; sod2 mitochondria ... See more keywords
Overexpression of SOD2/MnSOD promotes tumor growth and poor prognosis in TRAMP mice
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.222
Abstract: Mitochondrial superoxide dismutase (SOD2/MnSOD) is a primary line of antioxidant defense. Under aerobic conditions, its role detoxifying superoxide into H2O2 is crucial, as deduced from the early death of SOD2-/- KO mice after birth. SOD2… read more here.
Keywords: sod2; tramp mice; mice; tumor growth ... See more keywords
Protective effects of SOD2 overexpression in human umbilical cord mesenchymal stem cells on lung injury induced by acute paraquat poisoning in rats
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.020
Abstract: Aims: To study the protective effects and mechanisms of human umbilical cord mesenchymal stem cells (hUCMSCs) and overexpression of antioxidant gene SOD2 on lung injury by establishing a rat model of paraquat (PQ)‐induced lung injury.… read more here.
Keywords: umbilical cord; sod2; human umbilical; lung injury ... See more keywords
Sirt3-Sod2-mROS-Mediated Manganese Triggered Hepatic Mitochondrial Dysfunction and Lipotoxicity in a Freshwater Teleost.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c00585
Abstract: Exposure to excessive manganese (Mn) is toxic to humans and animals. However, the toxic effects and mechanisms of excessive Mn influencing the vertebrates have been highly overlooked. In the present study, dietary Mn overload significantly… read more here.
Keywords: sirt3; oxidative stress; mitochondrial dysfunction; sod2 ... See more keywords
Resorcinol alleviates alpha-terpineol-induced cell death in Schizosaccharomyces pombe via increased activity of the antioxidant enzyme Sod2.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS yeast research"
DOI: 10.1093/femsyr/foac052
Abstract: Alpha-terpineol, popular monoterpenoid alcohol, is known to cause cytotoxicity in a few cancer cells or to have antioxidant activity, but underlying mechanisms or apoptotic processes in yeast cell death should be understood. We used the… read more here.
Keywords: alpha terpineol; cell death; terpineol; sod2 ... See more keywords
POLYDATIN AMELIORATES TRAUMATIC BRAIN INJURY–INDUCED SECONDARY BRAIN INJURY BY INHIBITING NLRP3-INDUCED NEUROINFLAMMATION ASSOCIATED WITH SOD2 ACETYLATION
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002066
Abstract: ABSTRACT Traumatic brain injury (TBI) is a kind of disease with high morbidity, mortality, and disability, and its pathogenesis is still unclear. Research shows that nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) activation… read more here.
Keywords: tbi; sod2; brain injury; injury ... See more keywords
Homozygous damaging SOD2 variant causes lethal neonatal dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2019-106330
Abstract: Background Idiopathic dilated cardiomyopathy (DCM) is recognised to be a heritable disorder, yet clinical genetic testing does not produce a diagnosis in >50% of paediatric patients. Identifying a genetic cause is crucial because this knowledge… read more here.
Keywords: sod2; homozygous damaging; damaging sod2; dilated cardiomyopathy ... See more keywords
Decoding the role of SOD2 in sickle cell disease.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000527
Abstract: Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single point mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin polymerizes triggering red blood cell sickling and hemolysis, vaso-occlusion, and ischemia/reperfusion. Allied… read more here.
Keywords: cell; cell disease; sickle cell; sod2 ... See more keywords
Superoxide dismutase 2 ameliorates mitochondrial dysfunction in skin fibroblasts of Leber’s hereditary optic neuropathy patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.917348
Abstract: Background In Leber’s hereditary optic neuropathy (LHON), mtDNA mutations mediate mitochondrial dysfunction and apoptosis of retinal ganglion cells. Mitochondrial superoxide dismutase 2 (SOD2) is a crucial antioxidase against reactive oxygen species (ROS). This study aims… read more here.
Keywords: skin; apoptosis; mitochondrial dysfunction; dysfunction ... See more keywords