Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2‐tg heart
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DOI: 10.1016/j.freeradbiomed.2017.04.022
Abstract: Abstract SOD2 is the primary antioxidant enzyme neutralizing •O2− in mitochondria. Cardiac‐specific SOD2 overexpression (SOD2‐tg) induces supernormal function and cardiac hypertrophy in the mouse heart. However, the reductive stress imposed by SOD2 overexpression results in… read more here.
Keywords: heart; acetylation; sod2; sod2 mitochondria ... See more keywords