Two structures from a single gene: investigating the differential folding of SOD3
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.117
Abstract: Extracellular superoxide dismutase (SOD3) is a zinc and copper-containing enzyme that is responsible for the dismutation of the reactive oxygen species superoxide. SOD3 has previously been shown to exist in two distinct folding variants. These… read more here.
Keywords: two structures; single gene; folding variants; sod3 ... See more keywords
Inhibitory effects of superoxide dismutase 3 on Propionibacterium acnes-induced skin inflammation
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DOI: 10.1038/s41598-018-22132-z
Abstract: Propionibacterium acnes is a well-known commensal bacterium that plays an important role in the pathogenesis of acne and chronic inflammatory skin disease. In this study, we investigated the effect of superoxide dismutase 3 (SOD3) on… read more here.
Keywords: propionibacterium acnes; inflammation; sod3; skin inflammation ... See more keywords
Combined action of FOXO1 and superoxide dismutase 3 promotes MDA-MB-231 cell migration
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2049770
Abstract: Abstract Superoxide dismutase 3 (SOD3), one of SOD isozymes, maintains extracellular redox homeostasis through the dismutation reaction of superoxide. Loss of SOD3 in tumor cells induces oxidative stress and exacerbates tumor progression; however, interestingly, overexpression… read more here.
Keywords: sod3; cell migration; foxo1; mda 231 ... See more keywords
Changes in superoxide dismutase 3 (SOD3) expression in periodontal tissue during orthodontic tooth movement of rat molars and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament cells.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of orthodontics"
DOI: 10.1093/ejo/cjad005
Abstract: BACKGROUND/OBJECTIVES Hypoxia during orthodontic tooth movement (OTM) induces reactive oxygen species (ROS) production in periodontal tissues. Superoxide dismutase 3 (SOD3) is an anti-inflammatory enzyme that protects cells from ROS. This study investigated the expression and… read more here.
Keywords: sod3; hypoxia exposed; pdl cells; rat ... See more keywords
Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling
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DOI: 10.1186/s12931-018-0933-6
Abstract: BackgroundWork-place exposure to silica dust may lead to progressive lung inflammation culminating in the development of silicosis, an irreversible condition that can be complicated by onset of pulmonary hypertension (PH). The molecular mechanisms leading to… read more here.
Keywords: sod3; lung fibrosis; silica; vascular remodeling ... See more keywords
Superoxide dismutase 3 prevents early stage diabetic retinopathy in streptozotocin-induced diabetic rat model
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262396
Abstract: Purpose To identify the effects of superoxide dismutase (SOD)3 on diabetes mellitus (DM)-induced retinal changes in a diabetic rat model. Methods Diabetic models were established by a single intraperitoneal injection of streptozotocin (STZ) in Sprague-Dawley… read more here.
Keywords: sod3; superoxide dismutase; group; diabetic rat ... See more keywords
SOD3 Suppresses the Expression of MMP-1 and Increases the Integrity of Extracellular Matrix in Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11050928
Abstract: The superoxide dismutase (SOD) family functions as a reactive oxygen species (ROS)-scavenging system by converting superoxide anions into hydrogen peroxide in the cytosol (SOD1), mitochondria (SOD2), and extracellular matrix (SOD3). In this study, we examined… read more here.
Keywords: matrix fibroblasts; sod3; extracellular matrix; integrity extracellular ... See more keywords
Potential Role of Superoxide Dismutase 3 (SOD3) in Resistance to Influenza A Virus Infection
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DOI: 10.3390/antiox12020354
Abstract: Influenza A virus infection induces the production of excessive reactive oxygen species (ROS). Overproduction of ROS can overwhelm the antioxidant defense system, leading to increasing intensive oxidative stress. However, antioxidant defense against oxidative damage induced… read more here.
Keywords: sod3; virus infection; influenza virus;
Superoxide Dismutase-3 Downregulates Laminin α5 Expression in Tumor Endothelial Cells via the Inhibition of Nuclear Factor Kappa B Signaling
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DOI: 10.3390/cancers14051226
Abstract: Simple Summary Tumor-infiltrating lymphocytes determine cancer prognosis and the response to immunotherapy. The balance of laminin-α4/laminin-α5 isoforms in the endothelial basement membrane plays an instructive function in regulating the diapedesis of immune cells under inflammatory… read more here.
Keywords: sod3; superoxide dismutase; endothelial cells; expression ... See more keywords